# US 11,112,364 B2 · Molecular detection device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,112,364 B2 - Document ID: US11112364B2 - Status: Granted - Kind: B2 - Application number: 16/124,496 - Filed: 2018-09-07 - Published: 2019-04-18 - Granted: 2021-09-07 - Earliest claimed: 2017-09-08 - Assignees: Tsinghua University; Hon Hai Precision Industry Co., Ltd. - Applicants: Tsinghua University; Hon Hai Precision Industry Co., Ltd. - Inventors: Ying-Cheng Wang; Yuan-Hao Jin; Qun-Qing Li; Shou-Shan Fan - Web page: https://patentgrep.com/patent/US11112364B2 ## CPC - G01N 21/658: {enhancement Raman, e.g. surface plasmons} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract A molecular detection device is related. The device includes a carrier, a detector and a control computer. The carrier includes a substrate, a middle layer and a metal layer. The middle layer is sandwiched between the substrate and the middle layer. The detector is configured to detect molecules on a surface of the carrier. The control computer is connected to the detector and configured to analyze a detection result. The middle layer includes a base and a patterned bulge on the base, and the patterned bulge includes a plurality of strip-shaped bulges, the metal layer is on the patterned bulge. ## Claims ### Claim 1 A molecular detection device, consisting of: a carrier, the carrier consisting of a substrate, a middle layer, and a metal layer, wherein the middle layer is sandwiched between the substrate and the metal layer, a profile of the carrier is adaptable to match profiles of solid samples, and the carrier is in contact with the solid samples; a detector for detecting molecules on a surface of the carrier and creating a detection result; and a control computer, connected to the detector, and configured to analyze the detection result; wherein the substrate is a flexible substrate, the middle layer consists of a base and a patterned bulge on the base, the patterned bulge consists of a plurality of strip-shaped bulges, the plurality of strip-shaped bulges are continuous strip bulges and intersect with each other to form a substantially square shaped mesh and a plurality of holes are defined between the mesh, the metal layer is on the patterned bulge, the thickness of the metal layer ranges from 2 nanometers to 200 nanometers, the thickness of the base ranges from approximately 100 nanometers to approximately 200 nanometers, and the entire carrier is a flexible structure. ### Claim 2 (depends on 1) The device of claim 1, wherein the metal layer covers the entire surface of the patterned bulge. ### Claim 3 (depends on 1) The device of claim 1, wherein the metal layer is a discontinuous structure. ### Claim 4 (depends on 1) The device of claim 1, wherein the metal layer is only on side surfaces of the plurality of strip-shaped bulges and bottom surfaces of the plurality of holes. ### Claim 5 (depends on 1) The device of claim 1, wherein the carrier further comprises a carbon nanotube composite structure between the metal layer and the patterned bulge. ### Claim 6 (depends on 5) The device of claim 5, wherein the carbon nanotube composite structure comprises a carbon nanotube structure and a protective layer coated on the carbon nanotube structure, and the carbon nanotube structure comprises a plurality of carbon nanotubes intersecting each other. ### Claim 7 (depends on 6) The device of claim 6, wherein the protective layer comprises a material selected from the group consisting of metal, metal oxide, metal nitride, metal carbide, metal sulfide, silicon oxide, silicon nitride, and silicon carbide. ### Claim 8 (depends on 1) The device of claim 1, wherein the substrate comprises a material selected from the group consisting of polyethylene terephthalate, polyimide, polymethylmethacrylate, polydimethylsiloxane, and polyethylene naphthalate. ### Claim 9 (depends on 1) The device of claim 1, wherein the plurality of strip-shaped bulges comprises: a first plurality of first strip-shaped bulges; and a second plurality of second strip-shaped bulges, wherein the plurality of first strip-shaped bulges are aligned substantially parallel to each other and extending along a first direction, and the plurality of second strip-shaped bulges are aligned substantially parallel to each other and extending along a second direction which is different from the first direction. ### Claim 10 (depends on 9) The device of claim 9, wherein an angle between the first direction and the second direction is greater than or equal to 30 degrees and less than or equal to 90 degrees. ### Claim 11 (depends on 1) The device of claim 1, wherein each of the plurality of strip-shaped bulges has a width ranging from about approximately 20 nanometers to approximately about 150 nanometers and a height ranging from approximately about 20 nanometers to approximately about 500 nanometers, and a distance between adjacent two of the plurality of strip-shaped bulges ranging from approximately about 10 nanometers to approximately about 300 nanometers. ### Claim 12 (depends on 1) The device of claim 1, wherein the metal layer is a continuous structure. ### Claim 13 (depends on 1) The device of claim 1, further comprises a fixed element, the fixed element is adapted for fixing the carrier on a surface of a sample. ### Claim 14 (depends on 13) The device of claim 13, wherein the fixed element is a fixing tape or a bendable metal frame. ### Claim 15 (depends on 1) The device of claim 1, wherein the curvature of the carrier matches the curvature of the irregular surfaces of the solid samples. ### Claim 16 (depends on 1) The device of claim 1, wherein the base defines two surfaces and the two surfaces are opposite to each other, the patterned bulge is placed on the two surfaces of the base. ### Claim 17 (depends on 1) The device of claim 1, wherein the base and the patterned bulge are made of different materials.