# US 11,111,501 B2 · Fusarium head blight disease resistance > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,111,501 B2 - Document ID: US11111501B2 - Status: Granted - Kind: B2 - Application number: 16/492,679 - Filed: 2018-03-09 - Published: 2021-02-25 - Granted: 2021-09-07 - Earliest claimed: 2017-03-10 - Assignees: University College Dublin, National University of Ireland, Dublin;Agriculture and Food Development Authority (“Teagasc”) - Applicants: University College Dublin, National University of Ireland, Dublin; Agriculture and Food Development Authority (TEAGASC) - Inventors: Fiona Doohan; Ganesh Thapa; Lokandha Rao Gunupuru; Gerard Hehir; Ewen Mullins - Web page: https://patentgrep.com/patent/US11111501B2 ## CPC - C12N 15/8282: {for fungal resistance} - C07K 14/415: from plants - C12N 9/12: transferring phosphorus containing groups, e.g. kinases (2.7) - C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00) - C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00) ## Abstract A recombinant construct comprising a nucleotide sequence of SEQUENCE ID NO. 1 or a functional variant or functional fragment thereof is provided. Also provided are plant cells transformed with the gene and plant material, including plant cell cultures, seeds and plants, comprising the transformed plant cells. ## Claims ### Claim 1 A method of genetically transforming a plant material comprising the steps of introducing into one or more cells of the plant material with a recombinant construct comprising the nucleotide sequence of SEQ ID NO: 1 or a functional variant of SEQ ID NO: 1 having at least 90% sequence identity with SEQ ID NO: 1, and expressing the nucleotide sequence or the functional variant thereof in the plant material; wherein the expression of the nucleotide sequence or the functional fragment thereof provides Fusarium Head Blight (FHB) disease resistance in the plant. ### Claim 2 (depends on 1) The method of claim 1, wherein the one or more cells of the plant material is capable of overexpression of the nucleotide of SEQ ID NO:1 or the functional variant thereof. ### Claim 3 A method of producing a transformed plant or plant material having resistance to Fusarium Head Blight (FHB) disease, the method comprising the step of transforming a plant or plant material with a recombinant construct comprising the nucleotide sequence of SEQ ID NO: 1 or a functional variant of SEQ ID NO: 1 having at least 90% sequence identity with SEQ ID NO: 1, wherein the transformed plant or plant material exhibits FHB resistance. ### Claim 4 (depends on 3) The method of claim 3, wherein the plant material is selected from the group consisting of a plant cell, plant cell culture, plant tissue, and plant seed. ### Claim 5 (depends on 4) The method of claim 4, wherein the plant is a cereal. ### Claim 6 (depends on 5) The method of claim 5, wherein the cereal is selected from the group comprising maize, rice, wheat, barley, sorghum, millet, oats and rye. ### Claim 7 A transgenic plant or plant material comprising a recombinant construct comprising the nucleotide sequence of SEQ ID NO: 1 or a functional variant of SEQ ID NO: 1 having at least 90% sequence identity with SEQ ID NO: 1, wherein the transformed plant exhibits resistance to Fusarium Head Blight (FHB) disease. ### Claim 8 (depends on 7) The transgenic plant or plant material of claim 7, wherein the plant is a cereal. ### Claim 9 (depends on 8) The transgenic plant or plant material of claim 8, wherein the cereal is selected from the group consisting of maize, rice, wheat, barley, sorghum, millet, oats and rye. ### Claim 10 (depends on 7) The transgenic plant or plant material of claim 7, wherein the plant material is selected from the group consisting of a plant cell, plant cell culture, plant tissue and plant seed. ### Claim 11 (depends on 1) The method of claim 1, wherein the construct is an expression vector. ### Claim 12 (depends on 7) The transgenic plant of claim 7, wherein the construct is an expression vector. ### Claim 13 (depends on 1) The method of claim 1, wherein the nucleotide sequence encodes SEQ ID NO: 2 or a functional variant having at least 95% sequence identity with SEQ ID NO: 2. ### Claim 14 (depends on 3) The method of claim 3, wherein the nucleotide sequence encodes SEQ ID NO: 2 or a functional variant having at least 95% sequence identity with SEQ ID NO: 2. ### Claim 15 (depends on 7) The transgenic plant of claim 7, wherein the nucleotide sequence encodes SEQ ID NO: 2 or a functional variant having at least 95% sequence identity with SEQ ID NO: 2.