Methods and microorganisms for making 2,3-butanediol and derivatives thereof from C1 carbons
AssigneePrecigen, Inc.
InventorsXinhua Zhao, Mark Anton Held, Tina Huynh, Lily Yuin Chao, Na Trinh, Matthias Helmut Schmalisch, Bryan Yeh, James Kealey, Kevin Lee Dietzel
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Abstract
Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.
Claims18
A genetically modified microorganism capable of converting a Cl carbon to 2,3-BDO, wherein the microorganism is from the species Methylococcus capsulatus and comprises at least one heterologous gene encoding:
- i) an acetoin reductase;
- ii) an alpha-acetolactate decarboxylase;
- and/or iii) an acetolactate synthase.
Dependencies are inferred from the claim text.