Use of a small native peptide activator of SERCA pump for treatment of heart failure and other disorders characterized by cytosolic calcium overload
AssigneeBoard of Regents, The University of Texas System
InventorsEric N. Olson, Rhonda S. Bassel-Duby, Catherine A. Makarewich, Benjamin R. Nelson
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Abstract
The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
Claims7
A polynucleotide, comprising a polynucleotide sequence encoding a Dwarf open reading frame (DWORF) consisting of SEQ ID NO:
- 3, operatively linked to a heterologous cardiac-specific promoter.
A vector, comprising a polynucleotide sequence encoding a Dwarf open reading frame (DWORF) consisting of SEQ ID NO:
- 3, operatively linked to a heterologous cardiac-specific promoter.
Dependencies are inferred from the claim text.