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US 11,111,275 B2Granted
Compositions and methods for making and using virus-like particles (VLPs)
AssigneeUniversity of Massachusetts
InventorTrudy Gilkerson Morrison
Life of this patent
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Abstract
The present invention provides compositions and methods for using prophylactic and/or therapeutic vaccines to immunize subjects, and offspring of immunized female subjects, against respiratory syncytial virus (RSV). The invention also provides compositions and methods for producing increased yields of recombinant virus-like particles (VLPs).
Claims19
A vaccine comprising
- a) a recombinant Newcastle disease virus-like particle (ND VLP), said ND VLP comprises one or more recombinant chimeric mutation-stabilized pre-fusion F proteins that comprise a) SEQ ID NO:12, b) SEQ ID NO:10, or c) a combination of both SEQ ID NO:12 and SEQ ID NO:10, and
- b) a physiologically acceptable carrier.
Dependencies are inferred from the claim text.