Cyclic peptides multimers targeting alpha-4-beta-7 integrin

A homodimer of two moieties covalently linked together by an amide bond to a diphenic acid residue, the moieties both being of formula (I):

• wherein
• R1 is H;
• R2 is H;
• R3 is CH3;
• R4 is H;
• R5 is an amide of the formula —C(O)NR**R***, wherein R** is H and R*** is tert-butyl;
• R6 along with R7 together form the pyrrolidine ring of Pro;
• R8 is H;
• n is 1;
• wherein Z is an amino terminus of an amino acid;
• —C═O— adjacent L is the carboxy terminus of an amino acid;
• and L along with Z and —C═O— is a peptide having the following formula:
• Xy—Xz—X1—X2—X3
• wherein
• Xy is 3-aminomethyl-4-[4-(1-piperazinyl)-phenyl]-benzoic acid, in which the piperazinyl amine nitrogen at the 4-position of the piperazinyl ring is covalently bound via the amide bond to the diphenic acid residue to form the homodimer;
• Xz is absent;
• X1 is Leucine;
• X2 is Asp;
• and
• X3 is Thr;
• or a pharmaceutically acceptable salt thereof.