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US 11,111,266 B2Granted
Oxysterols and methods of use thereof
AssigneeSage Therapeutics, Inc.
InventorsFrancesco G. Salituro, Albert Jean Robichaud, Gabriel Martinez Botella, Boyd L. Harrison, Andrew Griffin
Life of this patent
Estimating the term…
Abstract
Compounds are provided according to Formula (A): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R5, R6, and RG are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
Claims25
A compound of Formula (I-63):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is alkyl;
- R2 is alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl and R3 is hydrogen, alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl, or
- R2 and R3, together with the carbon atom to which they are attached form a 3-8 membered ring;
- each of R4 and R5 is independently hydrogen, halo, or —ORC, wherein RC is hydrogen or C1-C6alkyl, or
- R4 and R5, together with the carbon atom to which they are attached form an oxo group;
- R6 is absent or hydrogen;
- and
- represents a single or double bond, wherein when one of is a double bond, the other is a single bond and R6 is absent;
- and wherein when both of are single bonds, R6 is hydrogen.
7 more elements
A compound of Formula (I-67):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is alkyl;
- each of R2 and R3 is independently hydrogen, alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl, or
- R2 and R3, together with the carbon atom to which they are attached form a 3-8 membered ring;
- each of R4 and R5 is independently hydrogen, halo, or —ORC, wherein RC is hydrogen or C1-C6alkyl, or
- R4 and R5, together with the carbon atom to which they are attached form an oxo group;
- R6 is absent or hydrogen;
- and
- represents a single or double bond, wherein when one of is a double bond, the other is a single bond and R6 is absent;
- and wherein when both of are single bonds, R6 is hydrogen.
7 more elements
A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
Dependencies are inferred from the claim text.