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US 11,111,261 B2Granted
Iron complex compounds for therapeutic use
AssigneePharmacosmos Holding A/S
InventorsTobias S. Christensen, Hans B. Andreasen
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Abstract
The present invention relates to iron complex compounds for therapeutic use which are low in arsenic, chromium, lead, cadmium, mercury and/or aluminum, compositions thereof and processes for preparing said iron complex compounds.
Claims25
A process for preparing an iron complex compound comprising the steps of
- (i) obtaining an iron preparation from iron pentacarbonyl, wherein the iron preparation comprises iron in a form selected from a water-soluble iron salt, an iron hydroxide, an iron oxide-hydroxide and a mixture of two or more thereof, wherein
- the amount of arsenic in the iron preparation does not exceed 4.5 μg per g of iron, and
- the amount of lead in the iron preparation does not exceed 1.5 μg per g of iron;
- (ii) reacting the iron preparation with a ligand in the presence of water so as to form the iron complex compound,
- (iii) recovering said iron complex compound, and
- (iv) formulating said iron complex compound for parenteral administration.
3 more elements
A process for preparing an iron complex compound comprising the steps of
- (i) obtaining an iron preparation by extracting an aqueous iron salt solution with an organic solvent, wherein the iron preparation comprises iron in a form selected from a water-soluble iron salt, an iron hydroxide, an iron oxide-hydroxide and a mixture of two or more thereof, wherein
- the amount of arsenic in the iron preparation does not exceed 4.5 μg per g of iron, and
- the amount of lead in the iron preparation does not exceed 1.5 μg per g of iron;
- (ii) reacting the iron preparation with a ligand in the presence of water so as to form the iron complex compound, and
- (iii) recovering said iron complex compound.
2 more elements
Dependencies are inferred from the claim text.