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US 11,111,224 B2Granted
Benzothia(di)azepine compounds and their use as bile acid modulators
AssigneeAlbireo AB
InventorsPer-Göran Gillberg, Ingemar Starke, Santosh S. Kulkarni
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Abstract
The invention relates to 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.
Claims10
A compound of formula (I)
- wherein
- M is selected from —CH2— and —NR6—;
- R1 is C1-4 alkyl;
- R2 is independently selected from the group consisting of hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, cyano, nitro, amino, N—(C1-4 alkyl)amino, N,N-di(C1-4 alkyl)-amino, N-(aryl-C1-4 alkyl)amino, C1-6 alkylcarbonylamino, C3-6 cycloalkylcarbonylamino, N—(C1-4 alkyl)aminocarbonyl, N,N-di(C1-4 alkyl)aminocarbonyl, C1-4 alkyloxycarbonylamino, C3-6 cycloalkyloxycarbonylamino, C1-4 alkylsulfonamido and C3-6 cycloalkylsulfonamido;
- n is an integer 1, 2 or 3;
- R3 is selected from the group consisting of hydrogen, halogen, cyano, C1-4 alkyl, C3-6 cycloalkyl, C1-4 alkoxy, C3-6 cycloalkyloxy, C1-4 alkylthio, C3-6 cycloalkylthio, amino, N—(C1-4 alkyl)amino and N,N-di(C1-4 alkyl)amino;
- One of R4 and R5 is carboxyl, and the other of R4 and R5 is selected from the group consisting of hydrogen, fluoro, C1-4 alkyl and C1-4 haloalkyl;
- R6 is selected from the group consisting of hydrogen and C1-4 alkyl;
- and
- R7 is selected from the group consisting of hydrogen and C1-4 alkyl;
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.