Hydroxyeicosatrienoic acid compounds and their use as therapeutic agents

A compound of Formula (0), or a pharmaceutically acceptable salt thereof:

• wherein:
• A is —COOR1, —OSO3R1, —OPO3(R1)2, or -G-HET;
• B is a bond each R1 independently is H or C1−6alkyl;
• R2 is H or OH;
• each —is a single or double bond, provided that (i) when —at bond 2 is a single bond, then —at bond 1 is a trans double bond and R2 is OH, and (ii) when —at bond 1 is a single bond, then —at bond 2 is a cis double bond and R2 is H;
• HET is an unsubstituted or substituted 5 to 10-membered heteroaryl group having 1, 2, 3, or 4 heteroatoms selected from the group consisting of N, S, or O;
• G is O, S, NH, or absent;
• Cx is an alkylene group having x carbon atoms;
• Cy is an alkyl group having y carbon atoms;
• x is 3, 4, 5, 6, or 7;
• y is 4, 5, 6, 7;
• and each carbon atom of the compound of Formula (0) independently is unsubstituted or substituted with one or more deuterium or fluorine atoms;
• with the proviso that when x is 6, y is 5, and each carbon atom of Formula (I) is unsubstituted, then A is not —COOH.