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US 11,111,208 B2Granted
Process for the preparation of safinamide mesylate intermediate
AssigneeRK Pharma Solutions LLC
InventorsRavishanker Kovi, Jayaraman Kannappan, Rajesh A Patel, Daxeshkumar Prakashbhai Patel
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Abstract
The present application provides methods for the synthesis of intermediates in the synthesis of Safinamide or a pharmaceutically acceptable salt thereof herein Safinamide Mesylate, that is substantially free of impurities.
Claims13
A method for the preparation of a compound, comprising:
- a condensation reaction of 4-hydroxybenzaldehyde of formula II with 1-(chloromethyl)-3-fluorobenzene of formula III, using potassium carbonate, and potassium iodide in a solvent, and removing the solvent after completion of the condensation reaction, therewith producing crude 4-((3-fluorobenzyl)oxy)benzaldehyde of formula IV;
- treating the crude with n-heptane to remove genotoxic impurities;
- dissolving the treated crude in dichloromethane and treating the solution with potassium carbonate;
- and
- treating the treated solution with n-heptane to afford 4-((3-fluorobenzyl)oxy)benzaldehyde of formula V having a purity greater than 99%.
2 more elements
Dependencies are inferred from the claim text.