Methods for preparing formaldehyde from carbon dioxide
AssigneeThe Trustees of Columbia University in the City of New York
InventorsGerard Parkin, Zack Strater, Michael Rauch
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Abstract
The present disclosure provides, inter alia, methods for preparing formaldehyde from carbon dioxide using bis(silyl)acetals, methods for incorporating carbon derived from carbon dioxide into a complex organic molecule derived from formaldehyde using bis(silyl)acetals, and methods for generating an isotopologue of a complex organic molecule derived from formaldehyde using bis(silyl)acetals.
Claims30
A method for preparing formaldehyde, comprising the steps of:
- (a) obtaining a bis(silyl)acetal;
- and
- (b) generating formaldehyde by any one of the following:
- adding a fluoride compound to a solution of the bis(silyl)acetal in a solvent;
- or
- (ii) reacting the bis(silyl)acetal with water in a solvent;
- or
- (iii) reacting the bis(silyl)acetal with an acid in a solvent.
A method for completing a transformation that involves formaldehyde, comprising substituting formaldehyde with a bis(silyl)acetal.
A method for incorporating carbon derived from carbon dioxide into a complex organic molecule derived from formaldehyde, comprising the steps of:
- (a) obtaining a bis(silyl)acetal by the reaction between carbon dioxide and a silane in the presence of a compound prepared from a multidentate ligand having the structure of:
- and B(C6F5)3, wherein the silane is R3SiH and R is selected from H, alkyl and aryl;
- and
- (b) substituting formaldehyde with the bis(silyl)acetal in a reaction that generates the complex organic molecule.
A method for carrying out a chemical reaction with a formaldehyde surrogate comprising replacing formaldehyde in the chemical reaction with a bis(silyl)acetal.
Dependencies are inferred from the claim text.