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US 11,110,450 B2Granted
Sample-reagent mixture thermal cycling
AssigneeHewlett-Packard Development Company, L.P.
InventorsBradley D. Chung, Alexander N. Govyadinov
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Abstract
A sample-reagent mixture is thermal cycled through a plurality of cycles. Each thermal cycle includes actuating a heater to heat the sample-reagent mixtures; and dispensing a fluid onto the sample-reagent mixture to cool the sample reagent mixture.
Claims14
An apparatus comprising:
- a heater;
- a fluid applicator;
- and
- a controller programmed to output control signals to thermal cycle a sample-reagent mixture through a plurality of cycles, each cycle comprising:
- outputting control signals actuating the heater to heat the sample-reagent mixture;
- and
- outputting control signals actuating the fluid applicator to dispense a fluid onto the sample-reagent mixture, wherein the fluid has a temperature that is lower than a temperature of the sample-reagent mixture to cool the sample reagent mixture during each cycle.
4 more elements
A method comprising:
- thermal cycling a sample-reagent mixture through a plurality of cycles, each cycle comprising:
- a controller actuating a heater to heat the sample-reagent mixture;
- and
- dispensing a fluid onto the sample-reagent mixture using a fluid applicator as controlled by the controller, wherein the fluid has a temperature that is lower than a temperature of the sample-reagent mixture to cool the sample reagent mixture during each cycle;
- and
- after the thermal cycling, imaging the sample-reagent mixture.
3 more elements
Dependencies are inferred from the claim text.