# US 11,110,294 B2 · Cooling system for tissue treatment system with both tissue and light source cooling > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,110,294 B2 - Document ID: US11110294B2 - Status: Granted - Kind: B2 - Application number: 16/569,693 - Filed: 2019-09-13 - Published: 2021-03-18 - Granted: 2021-09-07 - Earliest claimed: 2019-09-13 - Assignees: Candela Corporation - Applicants: Candela Corporation - Inventors: Kevin Schomacker; Dima Dubitsky - Web page: https://patentgrep.com/patent/US11110294B2 ## CPC - A61N 5/0616: {Skin treatment other than tanning} - A61B 18/203: {applying laser energy to the outside of the body} - A61F 7/007: {characterised by electric heating} - A61B 2018/00023: {closed, i.e. without wound contact by the fluid} - A61B 2018/00047: {using Peltier effect} - A61B 2018/00452: {Skin} - A61B 2018/0047: {Upper parts of the skin, e.g. skin peeling or treatment of wrinkles} - A61B 2018/1807: {using light other than laser radiation} - A61F 2007/0052: {for treatment of skin or hair} - A61F 2007/0056: {for cooling} - A61N 1/403: {for thermotherapy, e.g. hyperthermia} - A61N 5/067: using laser light - A61N 2005/0644: {Handheld applicators} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract A tissue treatment system includes an applicator connected with a base unit. The applicator includes a light source to generate light energy. A light guide directs the light energy to biological tissue and is configured to contact biological tissue. A thermoelectric cooler has a cold side and a hot side, with the cold side being associated with the light guide. A hot side plate is mounted to the hot side of the thermoelectric cooler. A first fluid passage is between the reservoir and the hot side plate to deliver cooling fluid over the hot side plate to chill the cold side of the thermoelectric cooler and cool the light guide and biological tissue. A second fluid passage is associated with the light source to direct cooling fluid to the light source prior to being returned to the reservoir. The first and second fluid passages define a single cooling fluid circulation loop. ## Claims ### Claim 1 A tissue treatment system comprising: a base unit having a power source and a reservoir for containing a cooling fluid, an applicator connected with the base unit via a cable, the applicator comprising: a tissue cooling element constructed and arranged to engage biological tissue for treatment, the tissue cooling element including channel structure associated there-with, a light source powered by the power source and constructed and arranged to generate light energy directed to the tissue cooling element and thus to the biological tissue, a first fluid passage between the reservoir and the channel structure of the tissue cooling element to deliver cooling fluid at a first temperature to the tissue cooling element to cool the biological tissue, such that the cooling fluid is heated to a second temperature upon heat exchange with the biological tissue, and a second fluid passage between the channel structure and the reservoir to return the cooling fluid to the reservoir, the second fluid passage being constructed and arranged to direct the cooling fluid, at the second temperature, to the light source to cool the light source prior to being returned to the reservoir, wherein the first and second fluid passages define a single cooling fluid circulation loop to cool both the tissue cooling element and the light source in series, and wherein a portion of each of the first and second fluid passages is disposed in the cable. ### Claim 2 (depends on 1) The system of claim 1, wherein the tissue cooling element is light guide or a transparent window. ### Claim 3 (depends on 1) The system of claim 1, wherein the cooling fluid is water or antifreeze. ### Claim 4 (depends on 1) The system of claim 1, wherein the light source is a flashlamp, a flashlamp and laser rod, or a diode laser. ### Claim 5 (depends on 1) The system of claim 1, further comprising a pump for pumping the cooling fluid from the reservoir, the system further comprising a heat exchanger constructed and arranged to keep a temperature of the cooling fluid pumped by the pump to near ambient temperature. ### Claim 6 (depends on 5) The system of claim 5, wherein the heat exchanger includes a radiator. ### Claim 7 (depends on 1) The system of claim 1, further comprising a pump for pumping the cooling fluid from the reservoir, the system further comprising a cooling module constructed and arranged to keep a temperature of the cooling fluid pumped by the pump to less than ambient temperature. ### Claim 8 (depends on 7) The system of claim 7, wherein the cooling module includes a thermoelectric cooling module or compressor refrigerator system. ### Claim 9 (depends on 1) The system of claim 1, wherein the light source is a diode laser and the second fluid passage communicates with channels in the diode laser. ### Claim 10 (depends on 1) The system of claim 1, wherein the light source includes a flashlamp and laser rod, and the light source is disposed in a bath of the cooling fluid created by the second fluid passage. ### Claim 11 (depends on 1) The system of claim 1, further comprising a heat source is provided in the second fluid passage to heat the cooling fluid prior to reaching the light source. ### Claim 12 (depends on 11) The system of claim 11, wherein the heat source is a heater or a radiator. ### Claim 13 (depends on 1) The system of claim 1, wherein the channel structure of the tissue cooling element has an inlet and the channel structure extends entirely through the tissue cooling element to an exit of the channel structure, wherein the first fluid passage is between the reservoir and the inlet of the channel structure and the second fluid passage is between the exit of the channel structure and the reservoir. ### Claim 14 A tissue treatment system comprising: a base unit having a power source and a reservoir for containing a cooling fluid, an applicator connected with the base unit via a cable, the applicator comprising: a light source powered by the power source and constructed and arranged to generate light energy, a light guide disposed adjacent to the light source for directing the light energy to biological tissue, the light guide being constructed and arranged to engage the biological tissue for treatment, at least one thermoelectric cooler having a cold side and a hot side, the cold side being associated with the light guide, and at least one hot side plate mounted to the hot side of the thermoelectric cooler, a first fluid passage structure between the reservoir and the hot side plate to deliver cooling fluid to the hot side plate to chill the cooling fluid to a first temperature and chill the cold side of the thermoelectric cooler and thus cool the light guide to cool the biological tissue, such that the cooling fluid is heated to a second temperature upon heat exchange with the biological tissue, and a second fluid passage structure between the hot side plate and the reservoir to return the cooling fluid to the reservoir, the second fluid passage structure being constructed and arranged to direct the cooling fluid, at the second temperature, to the light source to cool the light source prior to being returned to the reservoir, wherein the first and second fluid passage structures define a single cooling fluid circulation loop to cool both the light guide and the light source in series, and wherein a portion of each of the first and second fluid passage structure is disposed in the cable. ### Claim 15 (depends on 14) The system of claim 14, wherein the light guide is a prism. ### Claim 16 (depends on 15) The system of claim 15, wherein the cold side of the thermoelectric cooler is mounted directly to the prism. ### Claim 17 (depends on 15) The system of claim 15, further comprising at least one cold side plate having a first portion mounted to the cold side of the thermoelectric cooler and a second portion mounted to the prism, the hot side plate being mounted to a portion of the light source, wherein the first fluid passage structure is configured to deliver the cooling fluid to the hot side plate to chill the cold side of the thermoelectric cooler and the cold side plate and thus cool the light guide. ### Claim 18 (depends on 17) The system of claim 17, wherein two pairs of plates and two thermoelectric coolers are provided, each pair of plates including a cold side plate and a hot side plate with one thermoelectric cooler being disposed between associated cold side and hot side plates, the first fluid passage structure being disposed between the reservoir and each hot side plate to deliver cooling fluid to each hot side plate to chill each cold side plate and thus cool the light guide, and the second fluid passage structure being disposed between each hot side plate and the reservoir to return the cooling fluid to the reservoir, the second fluid passage structure being associated with the light source to direct cooling fluid from each hot side plate to the light source prior to being returned to the reservoir. ### Claim 19 (depends on 14) The system of claim 14, wherein the cooling fluid is water or antifreeze. ### Claim 20 (depends on 14) The system of claim 14, wherein two thermoelectric coolers and two hot side plates are provided, the first fluid passage structure being disposed between the reservoir and each hot side plate to deliver cooling fluid to each hot side plate to chill the cold side of each thermoelectric cooler and thus cool the light guide, and the second fluid passage structure being disposed between each hot side plate and the reservoir to return the cooling fluid to the reservoir, the second fluid passage structure being associated with the light source to direct cooling fluid from each hot side plate to the light source prior to being returned to the reservoir. ### Claim 21 A method of cooling a tissue treatment system, the system including a base unit having a power source and a reservoir for containing a cooling fluid, an applicator connected with the base unit via a cable with the applicator including a light source powered by the power source and constructed and arranged to generate light energy, and a tissue cooling element disposed adjacent to the light source for directing the light energy to biological tissue, with a portion of the tissue cooling element being configured to contact the biological tissue, the method comprising the steps of: providing first fluid passage structure from the reservoir and extending to be associated with the tissue cooling element, delivering the cooling fluid at a first temperature through the first passage structure to chill the tissue cooling element and thus cool the biological tissue, such that the cooling fluid is heated to a second temperature upon heat exchange with the biological tissue, providing second fluid passage structure from the tissue cooling element to the reservoir to return the cooling fluid to the reservoir, the second fluid passage structure being associated with the light source, and prior to returning the cooling fluid to the reservoir, directing the cooling fluid at the second temperature through the second passage structure to the light source to cool the light source, wherein the first and second fluid passage structures define a single cooling fluid circulation loop to cool both the tissue cooling element and the light source in series, and wherein a portion of each of the first and second fluid passage structure is disposed in the cable. ### Claim 22 (depends on 21) The method of claim 21, wherein the tissue cooling element is a transparent window or light guide including channel structure there-through, the channel structure communicating with the first and second passage structures so that the cooling fluid can flow through the channel structure. ### Claim 23 (depends on 21) The method of claim 21, wherein the tissue cooling element is a light guide in the form of a prism and the method further comprises: providing at least one thermoelectric cooler having a hot side and a cold side, with a hot side plate being coupled to the hot side of the thermoelectric cooler and the cold side of the thermoelectric cooler being associated with the light guide, delivering the cooling fluid through the first passage structure and to the hot side plate to cool the cold side of the thermoelectric cooler and the light guide and thus cool the biological tissue.