# US 11,110,204 B2 · Method of producing bioabsorbable membrane

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- Number: US 11,110,204 B2
- Document ID: US11110204B2
- Status: Granted
- Kind: B2
- Application number: 16/336,622
- Filed: 2017-06-02
- Published: 2020-11-19
- Granted: 2021-09-07
- Earliest claimed: 2016-09-30
- Assignees: GC Corporation
- Applicants: GC Corporation
- Inventors: Yuuhiro Sakai; Yusuke Shigemitsu; Kyohei Toyonaga; Hidetoshi Funabashi
- Web page: https://patentgrep.com/patent/US11110204B2

## CPC

- A61L 27/44: having a macromolecular matrix
- B29D 99/005: {Producing membranes}
- A61C 8/0006: {Periodontal tissue or bone regeneration (support means for endoprosthetic bone substitute or bone graft implants A61F2/2846)}
- A61F 2/2846: {Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects (nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006)}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 27/58: Materials at least partially resorbable by the body
- B05D 1/005: {Spin coating}
- B05D 7/24: for applying particular liquids or other fluent materials
- A61F 2250/0024: made from both porous and non-porous parts, e.g. adjacent parts
- A61L 2400/18: Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61L 2430/12: for dental implants or prostheses
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- B29D: PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE (making granules B29B9/00; making preforms B29B11/00)
- A61C: DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE (non-driven toothbrushes A46B; {tongue scrapers A61B17/24;} preparations for dentistry A61K6/00; preparations for cleaning the teeth or mouth A61K8/00, A61Q11/00)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- B05D: PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (conveying articles or workpieces through baths of liquid B65G, e.g. B65G49/02)

## Abstract

A method of producing a bioabsorbable membrane includes: forming a liquid membrane by spin-coating a coating liquid containing a first bioabsorbable polymer and a solvent; and forming a dense layer by causing a porous membrane containing a second bioabsorbable polymer to contact the liquid membrane.

## Claims

### Claim 1

A method of producing a bioabsorbable membrane including a first layer containing a first bioabsorbable polymer and a porous layer containing a second bioabsorbable polymer, the method comprising:
forming a liquid membrane by spin-coating a coating liquid containing the first bioabsorbable polymer and a solvent; and
after forming the liquid membrane, forming the first layer and the porous layer by causing a porous membrane containing the second bioabsorbable polymer to contact the liquid membrane such that a part of the liquid membrane permeates into the porous membrane and by evaporating the solvent contained in the liquid membrane by drying.

### Claim 2 (depends on 1)

The method of producing the bioabsorbable membrane according to claim 1, wherein when spin-coating the coating liquid, after a rotating base to which the coating liquid is applied is rotated at 50-500 rpm for a preliminary rotation, the rotating base is rotated at 500-3000 rpm for a main rotation.