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US 11,110,203 B2Granted
Decellularization of plant cell culture materials for tissue engineering and drug delivery
AssigneeWorcester Polytechnic Institute
InventorsJeannine Coburn, Glenn Gaudette, Nhi Phan
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Abstract
Provided herein are enzymatically decellularized cells, and methods of producing said cells, that can be used in a scaffold. The scaffolds featured herein are biocompatible and can comprise decellularized cells that have been modified to express a bioactive agent or molecule.
Claims12
A method for decellularizing cells, the method comprising:
- contacting a plurality of plant cells with a composition comprising a nuclease comprising DNase, thereby decellularizing the plurality of plant cells, wherein the plurality of plant cells are cellulose producing plant cells.
A method of producing a biocompatible scaffold in vitro, the method comprising:
- contacting cellulose producing cultured plant cells with a composition comprising a DNase, thereby producing decellularized cultured plant cells;
- and
- creating a biocompatible scaffold in vitro from the decellularized [modified] cultured plant cells.
Dependencies are inferred from the claim text.