Loading patent…
AssigneeNantong University
InventorsXin Tang, Cheng Sun, Gang Chen, Xiaosong Gu, Yumin Yang, Fei Ding, Yanpei Gong, Qianru He, Hongkui Wang, Mi Shen
Estimating the term…
A differential tissue-engineered nerve including motor-like nerves and sensory-like nerves. The motor-like nerve and the sensory-like nerve respectively includes a motor-like nerve outer tube and a motor-like nerve fiber in the outer tube as well as a sensory-like nerve outer tube and a sensory-like nerve fiber in the outer tube. Schwann cells and/or fibroblasts derived from motor nerves and sensory nerves are respectively contained in surfaces or pores of the motor-like and sensory-like nerve outer tubes. Transsynaptic signal molecules Neuroligin-1 and Neuroligin-2 are contained in surfaces or pores of the motor-like and sensory-like nerve fibers. Neuroligin-1 is selectively used to specifically promote synaptic remodeling of motor neurons, while Neuroligin-2 is selectively used to specifically promote synaptic remodeling of sensory neurons, so that repair efficiency of motor nerve cells and sensory nerve cells is improved.
A differential tissue-engineered nerve, wherein it comprises motor-like nerves and sensory-like nerves, the motor-like nerve comprises a motor-like nerve outer tube and a motor-like nerve fiber in the outer tube, Schwann cells and/or fibroblasts derived from motor nerves are contained in surface or pores of the motor-like nerve outer tube and a transsynaptic signal molecule Neuroligin-1 is contained in surface or pores of the motor-like nerve fiber;
Dependencies are inferred from the claim text.