# US 11,110,201 B2 · Devices including muscle matrix and methods of production and use

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- Number: US 11,110,201 B2
- Document ID: US11110201B2
- Status: Granted
- Kind: B2
- Application number: 15/881,911
- Filed: 2018-01-29
- Published: 2018-08-02
- Granted: 2021-09-07
- Earliest claimed: 2017-01-30
- Assignees: LifeCell Corporation
- Applicants: LifeCell Corporation
- Inventors: Li Ting Huang; Eric Stec; Nathaniel Bachrach; Hui Xu
- Web page: https://patentgrep.com/patent/US11110201B2

## CPC

- A61L 27/3604: {characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel}
- A61F 2/0063: {Implantable repair or support meshes, e.g. hernia meshes}
- A61F 2/08: Muscles; Tendons; Ligaments
- A61L 27/04: Metals or alloys
- A61L 27/16: obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/3645: {Connective tissue}
- A61L 27/367: {Muscle tissue, e.g. sphincter}
- A61L 27/3683: {subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment}
- A61L 27/3687: {characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents}
- A61L 27/3691: {characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation}
- A61L 27/3873: {Muscle tissue, e.g. sphincter}
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 27/58: Materials at least partially resorbable by the body
- A61F 2002/0081: {directly machined on the prosthetic surface, e.g. holes, grooves (A61F2/30771 takes precedence)}
- A61F 2002/0894: {Muscles}
- A61L 2430/30: for muscle reconstruction
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

Tissue compositions and methods of preparation thereof are provided. The tissue compositions can be used to treat or regenerate muscle tissue. The compositions can be configured to provide increased strength compared to other muscle matrices.

## Claims

### Claim 1

A tissue composition comprising:
a first muscle matrix layer and a second muscle matrix layer;
a supporting layer comprising a synthetic substrate having a first side and a second side opposite the first side; and
a first binding layer and a second binding layer, the binding layers comprising particulate acellular tissue matrix (ATM) that has been treated with a transglutaminase to attach the muscle matrix layers to the supporting layer, the first binding layer disposed adjacent to the first side of the supporting layer and adjacent to the first muscle matrix layer, the second binding layer disposed adjacent to the second side of the supporting layer and adjacent to the second muscle matrix layer.

### Claim 2 (depends on 1)

The tissue composition of claim 1, wherein the synthetic substrate is a mesh.

### Claim 3 (depends on 2)

The tissue composition of claim 2, wherein the synthetic substrate is a polypropylene mesh.

### Claim 4 (depends on 1)

The tissue composition of claim 1, wherein the particulate ATM comprises dermal or muscle tissue matrix.

### Claim 5 (depends on 1)

The tissue composition of claim 1, wherein the particulate ATM comprises rehydrated particles.

### Claim 6 (depends on 1)

The tissue composition of claim 1, wherein the particulate ATM comprises a porous structure.

### Claim 7 (depends on 1)

The tissue composition of claim 1, wherein the particulate ATM in the binding layer is cross-linked.