Back to results
US 11,110,180 B2Granted
Nucleic acid-polypeptide compositions and uses thereof
AssigneeAvidity Biosciences, Inc.
InventorsAndrew John Geall, Venkata Ramana Doppalapudi, Joel Daniel Arias, David Sai-Ho Chu, Michael Caramian Cochran, Rob Burke, Philip Kovach, Barbora Malecova
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
Claims20
A polynucleotide conjugate molecule comprising a binding moiety and a polynucleotide,
- wherein the polynucleotide comprises at least one 5′-vinylphosphonate modified non-natural nucleotide and at least one modified internucleotide linkage, or at least one inverted abasic moiety;
- and
- wherein the at least one 5′-vinylphosphonate modified non-natural nucleotide is:
- wherein B is a heterocyclic base moiety;
- R6 is selected from hydrogen, halogen, alkyl, alkoxy or aminoalkyl;
- and
- J is an internucleotide linking group linking to an adjacent nucleotide of the polynucleotide.
4 more elements
Dependencies are inferred from the claim text.