Composition and method for reducing hypoglycemia events in diabetes treatment
AssigneeMannKind Corporation
InventorsMarshall Grant, Simon R. Bruce, Robert A. Baughman
Life of this patent
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Abstract
An ultra-rapid acting insulin composition and method for treating hyperglycemia in patients with diabetes are disclose. The composition is an inhalable dry powder composition comprising fumaryl diketopiperazine and insulin for pulmonary delivery, which significantly reduces the rates of hypoglycemic events in patients in patients on mealtime insulin therapy.
Claims12
A method of treating diabetes comprising, administering to a patient with diabetes, exhibiting hypoglycemic events, a pharmaceutical composition comprising an inhalable dry powder comprising insulin and fumaryl diketopiperazine to replace rapid acting insulin analog used at mealtime, wherein the patient is not taking basal insulin and the pharmaceutical composition upon inhalation mimics native insulin release during a meal and significantly reduces the rate of hypoglycemic events in the patient who is subject to severe hypoglycemia with rapid acting insulin analog treatment.
Dependencies are inferred from the claim text.