# US 11,110,147 B2 · Collagen hydrolysates as a beneficial prebiotic and their effect on joint inflammation and osteoarthritis

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- Number: US 11,110,147 B2
- Document ID: US11110147B2
- Status: Granted
- Kind: B2
- Application number: 16/489,890
- Filed: 2018-03-01
- Published: 2020-03-05
- Granted: 2021-09-07
- Earliest claimed: 2017-03-15
- Assignees: Rousselot B.V.; University of Rochester
- Applicants: Rousselot B.V.; University of Rochester
- Inventors: Michael Zuscik; Janne Prawitt; Eric Schott; Robert Mooney; Christopher Farnsworth
- Web page: https://patentgrep.com/patent/US11110147B2

## CPC

- A61K 38/01: Hydrolysed proteins; Derivatives thereof
- A61K 38/014: {from connective tissue peptides, e.g. gelatin, collagen}
- A23K 20/147: Polymeric derivatives, e.g. peptides or proteins
- A23L 33/18: Peptides; Protein hydrolysates
- A61K 31/737: Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate (A61K31/727 takes precedence)
- A61K 38/39: Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The invention generally relates to pharmaceuticals and/or nutraceuticals. More particularly, the invention provides compositions of collagen-based peptides and specific digestive tract microbes useful for supporting or promoting joint, skin and/or bone health, and methods of preparation and use thereof. The invention further provides for the use of compositions of collagen-based peptides as a prebiotic for modulating the gut microbiome.

## Claims

### Claim 1

A method of administering a prebiotic to a subject comprising administering to the subject a prebiotic composition comprising hydrolyzed collagen peptides, wherein the hydrolyzed collagen peptides are type 1 hydrolyzed collagen peptides (hCol1) originating from bovine, or type 2 hydrolyzed collagen peptides (hCol2) originating from porcine, wherein the hCol1 have a mean molecular weight between about 1800 Da and about 3500 Da and the hCol2 have a mean molecular weight between about 1300 Da and about 3000 Da.

### Claim 2 (depends on 1)

The method of claim 1, wherein the gut microbiome in the subject is modulated.

### Claim 3 (depends on 1)

The method according to claim 1, wherein microbial diversity in the gut is increased.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the composition comprises at least 90% or at least 95% by weight hydrolyzed collagen peptides, based on the dry mass of the composition.

### Claim 5 (depends on 1)

The method according to claim 1, wherein said composition is formulated in a food or feed product, or a food or feed ingredient for oral administration.

### Claim 6 (depends on 1)

The method according to claim 1, wherein said composition is formulated as a dietary supplement for oral administration.

### Claim 7 (depends on 1)

The method according to claim 1, wherein said composition is administered to a subject each day for at least 7 days or for at least 14 days.

### Claim 8 (depends on 1)

The method according to claim 1, wherein said composition is administered to the subject at a daily dosage of between 0.5 g and 15 g.

### Claim 9

A method of preventing or treating joint inflammation in a subject comprising administering to the subject a composition comprising hydrolyzed collagen peptides, wherein the hydrolyzed collagen peptides are type 1 hydrolyzed collagen peptides (hCol1) originating from bovine, or type 2 hydrolyzed collagen peptides (hCol2) originating from porcine, wherein the hCol1 have a mean molecular weight between about 1800 Da and about 3500 Da and the hCol2 have a mean molecular weight between about 1300 Da and about 3000 Da.

### Claim 10 (depends on 9)

The method according to claim 9, wherein the joint inflammation is synovial inflammation.

### Claim 11 (depends on 9)

The method according to claim 9, wherein the composition comprises at least 90% or at least 95% by weight hydrolyzed collagen peptides, based on the dry mass of the composition.

### Claim 12

A method for preventing or treating osteoarthritis in a subject, comprising administering to the subject a composition comprising hydrolyzed collagen peptides, wherein the hydrolyzed collagen peptides are type 2 hydrolyzed collagen peptides (hCol2) that originate from porcine collagen from cartilage, wherein the hCol2 have a mean molecular weight between about 1300 Da and about 3000 Da.

### Claim 13 (depends on 12)

The method according to claim 12, wherein said osteoarthritis is posttraumatic osteoarthritis or obesity-induced osteoarthritis.

### Claim 14 (depends on 12)

The method according to claim 12, wherein said composition comprises at least 90% or at least 95% by weight hydrolyzed collagen peptides, based on the dry mass of the composition.

### Claim 15

A method of administering a chondroprotective agent to a subject comprising administering to the subject a composition comprising hydrolyzed collagen peptides, wherein the hydrolyzed collagen peptides are type 2 hydrolyzed collagen peptides (hCol2) originating from porcine, wherein the hCol2 have a mean molecular weight between about 1300 Da and about 3000 Da.

### Claim 16 (depends on 15)

The method according to claim 15, wherein the composition comprises at least 90% or at least 95% by weight hCol2, based on the dry mass of the composition.

### Claim 17 (depends on 15)

The method according to claim 15, wherein the hCol12 originates from porcine collagen from cartilage.