# US 11,110,145 B2 · Composition for protecting cell from oxidative stress comprising green tea extract which has modified amounts of ingredients

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- Number: US 11,110,145 B2
- Document ID: US11110145B2
- Status: Granted
- Kind: B2
- Application number: 16/110,371
- Filed: 2018-08-23
- Published: 2019-03-28
- Granted: 2021-09-07
- Earliest claimed: 2017-09-25
- Assignees: Amorepacific Corporation
- Applicants: Amorepacific Corporation
- Inventors: Hyungsu Kim; Ayoung Kim; Juewon Kim; Si Young Cho; Yong-Deog Hong
- Web page: https://patentgrep.com/patent/US11110145B2

## CPC

- A61K 36/82: Theaceae (Tea family), e.g. camellia
- A61K 31/353: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61P 39/06: Free radical scavengers or antioxidants
- A61K 2236/33: involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed is to provide a composition which is derived from a natural product and exhibits an excellent effect of protecting cells from oxidative stress and a method for preparing the same. The extract and composition according to one aspect of the present disclosure are derived from a natural product, thus are safe. It can prevent, ameliorate and treat oxidative stress and neuron damage. Therefore, it allows to improve the quality of life of the elderly population without concerns about side effects and promote development of the related industry.

## Claims

### Claim 1

A method for protecting cells from oxidative stress, comprising administering a composition comprising as an active ingredient a green tea extract containing 5 to 25% by weight of (−)-gallocatechin gallate (GCG) and 7 to 15% by weight of (−)-epigallocatechin gallate (EGCG) based on the total weight of the composition to a subject in need thereof,
wherein the total content of the GCG and EGCG in the extract is 40% by weight or less based on the total weight of the composition, and
wherein the GCG and the EGCG are contained in the green tea extract in a weight ratio of 1:1 to 1:2.5.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the extract is an extract obtained by at least one extraction with at least one selected from the group consisting of water and C1 to C4 alcohols.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the content of the extract in the composition is 1 to 100% by weight on a dry weight basis.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the dose of the active ingredient is 5 mg/kg/day to 1000 mg/kg/day on a dry weight basis.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the oxidative stress results from active oxygen species.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the oxidative stress results from lipid peroxidation in brain tissue.

### Claim 7 (depends on 6)

The method according to claim 6, wherein the oxidative stress results from the peroxidati on product malondialdehyde.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the cell is a brain cell or a neuron.