# US 11,110,142 B2 · Kampo medicine for improving cognitive function in Alzheimer-type dementia or mild cognitive impairment and treating at least one disease from the group consisting of overactive bladder, constipation, and chronic kidney diseases complicated by them with one drug

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- Number: US 11,110,142 B2
- Document ID: US11110142B2
- Status: Granted
- Kind: B2
- Application number: 16/777,534
- Filed: 2020-01-30
- Published: 2020-05-28
- Granted: 2021-09-07
- Earliest claimed: 2018-03-30
- Applicants: Yoshiteru Shimoide
- Inventors: Yoshiteru Shimoide
- Web page: https://patentgrep.com/patent/US11110142B2

## CPC

- A61K 36/718: Coptis (goldthread)
- A61K 36/076: Poria
- A61K 36/284: Atractylodes
- A61K 36/484: Glycyrrhiza (licorice)
- A61K 36/488: Pueraria (kudzu)
- A61K 36/539: Scutellaria (skullcap)
- A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras
- A61K 36/744: Gardenia
- A61K 36/756: Phellodendron, e.g. corktree
- A61P 1/10: Laxatives
- A61P 13/10: of the bladder
- A61P 13/12: of the kidneys
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided is a kampo medicine for treating multimorbidity of Alzheimer-type dementia or mild cognitive impairment and at least one disease from the group consisting of overactive bladder, constipation, and chronic kidney disease with one drug. A kampo medicine for treating multimorbidity with one drug, comprising a drug combination of orengedokuto and ryokeijutsukanto as an active ingredient, wherein the kampo medicine improves a cognitive function in Alzheimer-type dementia or mild cognitive impairment and relieves and treats at least one disease from overactive bladder, constipation, and chronic kidney disease complicated by Alzheimer-type dementia or mild cognitive impairment at a high rate with one drug.

## Claims

### Claim 1

A method for treating multimorbidity in a patient, comprising:
administering to the patient one kampo combination drug consisting of a drug combination of:
(i) orengedokuto, formulated from dried crude drugs Coptis Rhizome, Scutellaria Root, Phellodendron Bark, and Gardenia Fruit, wherein the mixed weights of the dried crude drugs in a daily dose for an adult are 1.5 g to 2.0 g for Coptis Rhizome, 3.0 g for Scutellaria Root, 1.5 g to 3.0 g for Phellodendron Bark, and 2.0 g to 3.0 g for Gardenia Fruit; and
(ii) ryokeijutsukanto, formulated from dried crude drugs Poria Sclerotium, Atractylodes Lancea Rhizome or Atractylodes Rhizome, Cinnamon Bark, and Glycyrrhiza, wherein the mixed weights of the dried crude drugs in a daily dose for an adult are 4.0 g to 6.0 g for Poria Sclerotium, 2.0 g to 3.0 g for Atractylodes Lancea Rhizome or Atractylodes Rhizome, 3.0 g to 4.0 g for Cinnamon Bark, and 1.0 g to 2.0 g for Glycyrrhiza,
wherein the one kampo combination drug relieves and treats at least one disease selected from the group consisting of: an overactive bladder, constipation, and chronic kidney disease.

### Claim 2

A method for treating multimorbidity in a patient, comprising:
administering to the patient one kampo combination drug consisting of a drug combination of:
(i) orengedokuto, formulated from dried crude drugs Coptis Rhizome, Scutellaria Root, Phellodendron Bark, and Gardenia Fruit, wherein the mixed weights of the dried crude drugs in a daily dose for an adult are 1.5 g to 2.0 g for Coptis Rhizome, 3.0 g for Scutellaria Root, 1.5 g to 3.0 g for Phellodendron Bark, and 2.0 g to 3.0 g for Gardenia Fruit; and
(ii) ryokeijutsukanto, formulated from dried crude drugs Poria Sclerotium, Atractylodes Lancea Rhizome or Atractylodes Rhizome, Cinnamon Bark, and Glycyrrhiza, wherein the mixed weights of the dried crude drugs in a daily dose for an adult are 4.0 g to 6.0 g for Poria Sclerotium, 2.0 g to 3.0 g for Atractylodes Lancea Rhizome or Atractylodes Rhizome, 3.0 g to 4.0 g for Cinnamon Bark, and 1.0 g to 2.0 g for Glycyrrhiza,
wherein the one kampo combination drug relieves and treats constipation, and chronic kidney disease.