Live attenuated parasitic vaccine
AssigneeOhio State Innovation Foundation
InventorBradford McGwire
Life of this patent
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Abstract
Disclosed herein is an avirulent live vaccine that involves a recombinant protozoan from the order Trypanosomatida having a knocked out or silenced cyclophilin gene, wherein the cyclophilin gene comprises T. cruzi cyclophilin 19 (TcCyp19) gene, or an orthologue thereof. Also disclosed is a method or inducing a protective immune response in a subject that involves administering to the subject a vaccine disclosed herein. Also disclosed is a method of treating or preventing Chagas disease, African trypanosomiasis, and/or leishmaniasis in a subject that involves administering to the subject a vaccine disclosed herein.
Claims9
An avirulent live vaccine, comprising a recombinant protozoan from the order Trypanosomatida having a knocked out or silenced cyclophilin 19 (cyp19) gene.
Dependencies are inferred from the claim text.