Methods and reagents for modulating macrophage phenotype
AssigneeNew York University
InventorsDafna Bar-Sagi, Jane Cullis, Craig Ramirez
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Abstract
The present invention is directed to methods of inducing a phenotypic change in a population of monocytes and/or macrophages. The method includes administering to the population of monocytes and/or macrophages, a macrophage stimulating agent coupled to a carrier molecule, wherein the carrier molecule facilitates macropinocytic uptake of the agent by monocytes and macrophages in the population and is defective in neonatal Fc receptor binding, wherein the administering induces a phenotypic change in the monocytes and macrophages in the population.
Claims16
A method of inducing a phenotypic change in a population of monocytes and/or macrophages, said method comprising:
- administering to the population of monocytes and/or macrophages, a macrophage stimulating agent coupled to a carrier molecule, wherein said carrier molecule is selected from (i) a modified or variant human albumin protein or fragment thereof and (ii) a modified or variant human immunoglobulin G protein or fragment thereof, wherein the carrier molecule is defective in neonatal Fc receptor (FcRn) binding, and wherein said carrier molecule and agent are taken up via macropinocytosis by monocytes and/or macrophages of the population, thereby inducing a phenotypic change in said monocytes and/or macrophages.
Dependencies are inferred from the claim text.