# US 11,110,120 B2 · Compositions comprising cinnamaldehyde and zinc and methods of using such compositions

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- Number: US 11,110,120 B2
- Document ID: US11110120B2
- Status: Granted
- Kind: B2
- Application number: 15/573,562
- Filed: 2016-05-24
- Published: 2018-05-10
- Granted: 2021-09-07
- Earliest claimed: 2015-06-05
- Assignees: Societe des Produits Nestle S.A.
- Applicants: Nestec S.A.
- Inventors: Susana Camacho; Stephanie Michlig Gonzalez; Lucas Actis Goretta; Jenny Meylan Merlini; Johannes Le Coutre
- Web page: https://patentgrep.com/patent/US11110120B2

## CPC

- A61K 33/30: Zinc; Compounds thereof
- A23C 9/00: Milk preparations; Milk powder or milk powder preparations (mixtures of whey with milk products or milk components A23C21/06; preservation of milk or milk preparations A23B11/10)
- A23L 23/00: Soups; Sauces (soya sauce A23L27/50; salad dressings, mayonnaise or ketchup A23L27/60); Preparation or treatment thereof
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/30: {Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence)}
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 31/11: Aldehydes
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/12: Antihypertensives
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23C: DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF (preservation thereof A23B11/00)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Compositions comprise an amount of cinnamaldehyde that is orally tolerable, thus avoiding an unpleasant mouth feeling, and also tolerable in the gastrointestinal tract. The cinnamaldehyde is supplemented by zinc, and the combination can be effective to increase at least one of energy expenditure, sympathetic nervous system activity, or fat oxidation. The composition comprising the combination of cinnamaldehyde and zinc can be used in a method to support weight management or promote weight loss, a method for preventing obesity or overweight, and a method for treating obesity or overweight. The composition can improve one or more of insulin sensitivity, glucose tolerance, cognitive performance, cognition, mood or memory. The composition can achieve a therapeutic effect selected from the group consisting of blood vessel dilation, reduced blood pressure, increased delivery of blood flow to tissues in the body, stimulation of protein synthesis, increased release of growth factors, enhanced immune function, and combinations thereof.

## Claims

### Claim 1

A method for treating or reducing a risk and/or a severity of high blood pressure, the method comprising administering a food product to a human in need thereof and who is not obese or overweight,
the food product comprising cinnamaldehyde and zinc in a cinnamaldehyde:zinc ratio in molarity of 1:0.5 to 1:0.005,
the food product is selected from the group consisting of a beverage, a cereal bar, a dairy bar, a soup, a breakfast cereal, muesli, a candy, a cookie, a biscuit, a cracker, a dairy product, a tablet, a capsule, a pastille and a liquid,
the food product comprising the cinnamaldehyde at a flavoring concentration of from 31.87 ppm to 6191 ppm, and
the food product comprises at least one of zinc chloride, zinc sulfate, zinc lactate or zinc citrate that provides at least a portion of the zinc.

### Claim 2 (depends on 1)

The method of claim 1, wherein the food product is administered to the human at least once a day for at least one week.

### Claim 3 (depends on 1)

The method of claim 1, wherein the cinnamaldehyde:zinc ratio in molarity is 1:0.03.

### Claim 4 (depends on 1)

The method of claim 1, wherein at least a portion of the cinnamaldehyde is at least one of isolated cinnamaldehyde or chemically synthesized cinnamaldehyde.

### Claim 5 (depends on 1)

The method of claim 1, wherein the cinnamaldehyde:zinc ratio in molarity is about 1:0.03.