Modulators of toll-like receptors

A compound of Formula II:

• or a pharmaceutically acceptable salt thereof, wherein:
• Y—Z is —CR4R5—CR4R5;
• L1 is —NH— or —O—;
• R1 is C1-C6 alkyl C3-C12 saturated carbocyclyl, C4-C20 saturated carbocyclylalkyl, or C6-C20 arylalkyl;
• X1 is —CH2;
• D is phenyl substituted with -L2-NR6R7;
• each L2 is independently C1-C6 alkylene;
• each R3 is independently halogen, cyano, or C1-C6 haloalkyl;
• n is 0 or 1;
• R4 and R5 are each H;
• R6 and R7 are each independently H, C1-C6 alkyl, or C4-C20 saturated carbocyclylalkyl, —C(O)R8, —S(O)R8, —S(O)2R8, or —C(O)OR8;
• or
• R6 and R7, taken together with the nitrogen to which they are both attached, form a 4-6 membered saturated heterocycle comprising 0 to 2 heteroatoms selected from N, O, or S;
• and
• R8 is H or C1-C6 alkyl.