# US 11,110,068 B2 · Compositions comprising a dendrimer-resveratrol complex and methods for making and using the same

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- Number: US 11,110,068 B2
- Document ID: US11110068B2
- Status: Granted
- Kind: B2
- Application number: 16/522,459
- Filed: 2019-07-25
- Published: 2020-07-23
- Granted: 2021-09-07
- Earliest claimed: 2013-08-21
- Assignees: Concordia University
- Applicants: Concordia University
- Inventors: Abhay Singh Chauhan; Eric Andrew Newenhouse; Armin Henry Gerhardt
- Web page: https://patentgrep.com/patent/US11110068B2

## CPC

- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 9/10: Dispersions; Emulsions
- A61K 9/5146: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/595: {Polyamides, e.g. nylon (polyamino acids A61K47/62)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.

## Claims

### Claim 1

A method of treating a skin condition or disorder, the method comprising topically administering to skin or mucous membrane of a subject in need thereof a therapeutically effective amount of a semi-solid composition comprising a dendrimer-resveratrol complex, wherein the concentration of dendrimer is less than 0.40 mM, wherein at least 50%, by weight, of the resveratrol associated with dendrimer permeates the skin in 20 minutes or less in a transdermal permeation study utilizing Franz Diffusion Cells and rat skin samples.

### Claim 2

A method of preparing a composition comprising a dendrimer-resveratrol complex, the method comprising:
mixing resveratrol, dendrimer, water and essentially no organic solvent to form an aqueous mixture comprising a dendrimer-resveratrol complex; and filtering the mixture to form the composition comprising a dendrimer-resveratrol complex, the composition being essentially free of organic solvent, wherein the concentration of dendrimer is less than 0.40 mM, and the aqueous solubility of the resveratrol associated with the dendrimer being at least 40 times greater than the aqueous solubility of neat resveratrol, as measured at pH 7.