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US 11,110,066 B2Granted
Implantable devices for delivery of bioactive agents
AssigneeSorrento Therapeutics, Inc.
InventorsJeremy Ollerenshaw, Emily Reichart, Russell F. Ross
Life of this patent
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Abstract
An implantable delivery device and method for utilizing the device to delivery a bioactive agent to a subject in need thereof is described. The device includes a pattern of structures fabricated on a surface of the device to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The device may be located adjacent tissue such as an endovascular implant or a perivascular implant, and may deliver the bioactive agent without triggering an immune or foreign body response to the bioactive agent.
Claims20
A fully implantable delivery device configured to deliver a bioactive agent to a subject, the device comprising:
- the bioactive agent;
- a wall having a surface;
- a plurality of nanostructures extending from the surface of the wall, at least a portion of the nanostructures having a cross-sectional dimension of greater than about 5 nanometers and less than about 500 nanometers, and a height of greater than about 5 nanometers to less than about 1 micrometer, and wherein at least a portion of the nanostructures have a center-to-center spacing of greater than about 50 nanometers to less than about 1 micrometer, and
- a plurality of microstructures extending from the surface of the wall, at least a portion of the microstructures having a cross-sectional dimension of greater than about 500 nanometers and less than about 10 micrometers and a height of from about 20 nanometers to about 1 micrometer, wherein the cross-sectional dimension of each nanostructure of the plurality of nanostructures is smaller than the cross-sectional dimension of each microstructure of the plurality of microstructures;
- wherein the plurality of nanostructures and plurality of microstructures are arranged in a fractal dimension of greater than about 1;
- and
- wherein the surface containing the plurality of nanostructures and plurality of microstructures has an average surface roughness, as determined by an arithmetical mean height of a surface area roughness parameter as defined by ISO 25178, between about 10 nanometers and about 200 nanometers.
4 more elements
A fully implantable delivery device configured to deliver a bioactive agent to a subject, the device comprising:
- the bioactive agent;
- a wall having a surface;
- a plurality of nanostructures extending from the surface of the wall, at least a portion of the nanostructures having a cross-sectional dimension of greater than about 5 nanometers and less than about 300 nanometers, and a height of greater than about 5 nanometers to less than about 1 micrometer, and wherein at least a portion of the nanostructures have a center-to-center spacing of greater than about 50 nanometers to less than about 1 micrometer, and
- a plurality of microstructures extending from the surface of the wall, at least a portion of the microstructures having a cross-sectional dimension of greater than about 500 nanometers and less than about 10 micrometers and a height of from about 20 nanometers to about 1 micrometer, wherein the cross-sectional dimension of each nanostructure of the plurality of nanostructures is smaller than the cross-sectional dimension of each microstructure of the plurality of microstructures;
- wherein the plurality of nanostructures and plurality of microstructures are arranged in a fractal dimension of greater than about 1;
- wherein the surface containing the plurality of nanostructures and plurality of microstructures has an average surface roughness, as determined by an arithmetical mean height of a surface area roughness parameter as defined by ISO 25178, between about 10 nanometers and about 200 nanometers.
3 more elements
A fully implantable delivery device for delivery of a bioactive agent to a subject, the device comprising:
- a wall having a surface;
- a plurality of nanostructures extending from the surface of the wall, at least a portion of the nanostructures having a cross-sectional dimension of greater than about 5 nanometers and less than about 500 nanometers, and a height of greater than about 5 nanometers to less than about 1 micrometer, and wherein at least a portion of the nanostructures have a center-to-center spacing of greater than about 50 nanometers to less than about 1 micrometer,
- a plurality of microstructures extending from the surface of the wall, at least a portion of the microstructures having a cross-sectional dimension of greater than about 500 nanometers and less than about 10 micrometers and a height of from about 20 nanometers to about 1 micrometer;
- and
- a reservoir defined by the wall and containing the bioactive agent suitable for delivering to the subject using the implantable delivery device,
- wherein the entire implantable delivery device is suitable for implanting in the subject and configured to interact with tissue near a site of implantation within the subject;
- wherein the plurality of nanostructures and plurality of microstructures are arranged in a fractal dimension of greater than about 1;
- and
- wherein the surface containing the plurality of nanostructures and plurality of microstructures has an average surface roughness, as determined by an arithmetical mean height of a surface area roughness parameter as defined by ISO 25178, between about 10 nanometers and about 200 nanometers.
6 more elements
Dependencies are inferred from the claim text.