# US 11,110,060 B2 · Compositions and methods for delivering pharmaceutical agents

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- Number: US 11,110,060 B2
- Document ID: US11110060B2
- Status: Granted
- Kind: B2
- Application number: 16/759,054
- Filed: 2018-10-25
- Published: 2020-10-01
- Granted: 2021-09-07
- Earliest claimed: 2017-10-25
- Assignees: Arizona Board of Regents on Behalf of the University of Arizona
- Applicants: Arizona Board of Regents on Behalf of the University of Arizona
- Inventors: Heidi M. Mansour; Rick G. Schnellmann; Maria F. Acosta
- Web page: https://patentgrep.com/patent/US11110060B2

## CPC

- A61K 9/1623: {Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules}
- A61K 9/1617: {Organic compounds, e.g. phospholipids, fats}
- A61K 9/1694: {resulting in granules or microspheres of the matrix type containing more than 5% of excipient}
- A61K 31/185: Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids (hydroxamic acids A61K31/16; peroxy acids A61K31/327)
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61K 9/1641: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided herein are compositions and methods for wound healing. In particular, provided herein are spray dried suramin for use in wound healing and other applications.

## Claims

### Claim 1

A composition, comprising: suramin nanoparticles or microparticles and a pharmaceutically acceptable carrier, wherein said pharmaceutically acceptable carrier is selected from the group consisting of a) trehalose and b) a mixture of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphoethanolamine-poly(ethylene glycol) (DPPE-PEG).

### Claim 2 (depends on 1)

The composition of claim 1, wherein said suramin and trehalose are present at a molar ratio of 20:80 to 80:20.

### Claim 3 (depends on 1)

The composition of claim 1, wherein said suramin and trehalose are present at a molar ratio of 50:50.

### Claim 4 (depends on 1)

The composition of claim 1, wherein said suramin and said mixture of DPPC and DPPE-PEG are present at a molar ratio of 50:50.

### Claim 5 (depends on 1)

The composition of claim 1, wherein said suramin is encapsulated by said mixture of DPPC and DPPE-PEG.

### Claim 6 (depends on 1)

The composition of claim 1, wherein said DPPC and DPPE-PEG are present at a 95:5 molar ratio.

### Claim 7 (depends on 1)

The composition of claim 1, wherein said PEG has an average molecular weight of 2000 g/mol to 5000 g/mol.

### Claim 8 (depends on 1)

The composition of claim 1, wherein said composition is prepared by spray drying.

### Claim 9 (depends on 1)

The composition of claim 1, wherein said nanoparticles or microparticles are amorphous.

### Claim 10 (depends on 1)

The composition of claim 1, wherein said nanoparticles or microparticles are generated by a method, comprising:
a) preparing a first solution comprising said suramin in an organic solvent and a second solution comprising said pharmaceutically acceptable carrier in said organic solvent; and
b) co-spraying said first and second solutions using a spray drying apparatus to generate said nanoparticles or microparticles.

### Claim 11 (depends on 10)

The composition of claim 10, wherein said organic solvent is methanol.

### Claim 12 (depends on 1)

A method of treating wounds in a subject of need thereof, the method comprising topically administering the composition of claim 1 to the wound of the subject.

### Claim 13 (depends on 12)

The method of claim 12, wherein said wound is selected from the group consisting of an acute wound, a chronic wound and ulcer.

### Claim 14 (depends on 12)

The method of claim 12, wherein said subject has diabetes or mucositis.

### Claim 15 (depends on 12)

The method of claim 12, further comprising administering an additional treatment for said wound.