# US 11,110,048 B2 · Topical sanitizing formulations and uses thereof

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- Number: US 11,110,048 B2
- Document ID: US11110048B2
- Status: Granted
- Kind: B2
- Application number: 16/735,547
- Filed: 2020-01-06
- Published: 2020-05-07
- Granted: 2021-09-07
- Earliest claimed: 2012-07-23
- Assignees: Innovative BioDefense, Inc.
- Applicants: Innovative BioDefense, Inc.
- Inventors: Jesse Cozean; Colette Cozean; Susan Goldsberry
- Web page: https://patentgrep.com/patent/US11110048B2

## CPC

- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61K 8/31: Hydrocarbons
- A61K 8/34: Alcohols
- A61K 8/416: {Quaternary ammonium compounds (A61K8/35 takes precedence)}
- A61K 8/43: Guanidines
- A61K 8/678: {Tocopherol, i.e. vitamin E}
- A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K 31/14: Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205)
- A61K 31/155: Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 31/717: Celluloses
- A61K 31/785: Polymers containing nitrogen
- A61K 33/30: Zinc; Compounds thereof
- A61K 36/61: Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 17/00: Drugs for dermatological disorders
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/02: Local antiseptics
- A61P 31/04: Antibacterial agents
- A61P 31/10: Antimycotics
- A61P 31/12: Antivirals
- A61Q 17/005: {Antimicrobial preparations}
- A61Q 19/007: {Preparations for dry skin}
- A61Q 19/10: Washing or bathing preparations
- A61K 2800/30: Characterized by the absence of a particular group of ingredients
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Several embodiments disclosed herein relate to formulations having antimicrobial and/or sanitizing effects, and uses of the same. In particular, the formulations and methods of using same provide, in several embodiments, an immediate and a persistent antimicrobial effect against a broad spectrum of microorganisms.

## Claims

### Claim 1

An antimicrobial formulation comprising:
a quaternary ammonium salt in an amount ranging from about 0.10% to about 0.40% by weight of the formulation,
farnesol in an amount ranging from about 0.25% to about 0.60% by weight of the formulation;
ethyl alcohol in an amount ranging from about 8% to about 20% by weight of the formulation; and
water in an amount ranging from about 60% to about 75% by weight of the formulation,
wherein the formulation is capable of killing at least 85% of both gram-positive and gram-negative bacteria at 4 hours post-application of the formulation.

### Claim 2 (depends on 1)

The antimicrobial formulation of claim 1, wherein the killing effect persists for at least 6 hours post-application.

### Claim 3 (depends on 1)

The antimicrobial formulation of claim 1, wherein the quaternary ammonium salt is selected from the group consisting of benzethonium chloride, benzalkonium chloride, and combinations thereof.

### Claim 4 (depends on 3)

The antimicrobial formulation of claim 3, further comprising panthenol in an amount ranging from about 0.25% to about 0.60% by weight of the formulation.

### Claim 5 (depends on 4)

The antimicrobial formulation of claim 4, further comprising tocopheryl acetate in an amount ranging from about 0.05% to about 0.5% by weight of the formulation.

### Claim 6 (depends on 4)

The antimicrobial formulation of claim 4, further comprising chlorhexidine gluconate in an amount ranging from about 0.10% to about 0.40% by weight of the formulation.

### Claim 7 (depends on 4)

The antimicrobial formulation of claim 4, further comprising polyquaternium-10 in an amount ranging from about 0.05% to about 1.0% by weight of the formulation.

### Claim 8 (depends on 4)

The antimicrobial formulation of claim 4, further comprising glycerine in an amount ranging from about 1.5% to about 3.5% by weight of the formulation.

### Claim 9 (depends on 4)

The antimicrobial formulation of claim 4, further comprising polyaminopropyl biguanide in an amount ranging from about 0.01% to about 3.0% by weight of the formulation.

### Claim 10 (depends on 4)

The antimicrobial formulation of claim 4, further comprising one or more zinc salts in an amount ranging from about 0.05% to about 0.60% by weight of the formulation.

### Claim 11 (depends on 10)

The antimicrobial formulation of claim 10, wherein the one or more zinc salts comprises zinc lactate.

### Claim 12 (depends on 10)

The antimicrobial formulation of claim 10, wherein the one or more zinc salts comprises zinc gluconate.

### Claim 13 (depends on 10)

The antimicrobial formulation of claim 10, further comprising dimethicone in an amount ranging from about 0.5% to about 2.0% by weight of the formulation, and one or more additional emollient compounds.

### Claim 14 (depends on 13)

The antimicrobial formulation of claim 13, wherein the formulation is free of triclosan.

### Claim 15 (depends on 1)

A method of killing bacteria on the skin of a subject, comprising applying an effective amount of the antimicrobial formulation of claim 1 to the skin of the subject.