# US 11,110,047 B2 · Oral care compositions including cyclic anhydrides

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- Number: US 11,110,047 B2
- Document ID: US11110047B2
- Status: Granted
- Kind: B2
- Application number: 15/670,009
- Filed: 2017-08-07
- Published: 2019-02-07
- Granted: 2021-09-07
- Earliest claimed: 2017-08-07
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company
- Inventors: Chun Huang; Guofeng Xu; Cajetan Dogo-Isonagie
- Web page: https://patentgrep.com/patent/US11110047B2

## CPC

- A61K 8/4973: {with oxygen as the only hetero atom}
- A61K 8/21: Fluorides; Derivatives thereof
- A61K 8/22: Peroxides; Oxygen; Ozone
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A whitening composition and methods for whitening teeth and generating a whitening agent with the same are provided. The whitening composition may include an orally acceptable vehicle, a source of hydrogen peroxide that provides hydrogen peroxide, and a cyclic anhydride that generates a whitening agent with the hydrogen peroxided provided by the source of hydrogen peroxide. The whitening agent may be a peracid, such as a succinic peracid.

## Claims

### Claim 1

A mouthwash composition, comprising an orally acceptable vehicle, sodium carbonate, a source of hydrogen peroxide that provides hydrogen peroxide, and a cyclic anhydride that generates a peracid with the hydrogen peroxide provided by the source of hydrogen peroxide; and
wherein the molar ratio of the cyclic anhydride to the hydrogen peroxide provided by the source of hydrogen peroxide is from about 0.8:1 to about 1.3:1;
wherein the orally acceptable vehicle further comprises one or more ingredient selected from antibacterial agents, anticalculus agents, humectants, surfactants and cooling agents; and
wherein the cyclic anhydride is not a polymer-based cyclic anhydride.

### Claim 2 (depends on 1)

The mouthwash composition of claim 1, wherein the source of hydrogen peroxide comprises at least one of hydrogen peroxide, urea peroxide, calcium peroxide, sodium perborate, a polyvinylpyrrolidone (PVP) hydrogen peroxide complex, and sodium percarbonate.

### Claim 3 (depends on 1)

The mouthwash composition of claim 1, wherein the source of hydrogen peroxide is present in the whitening composition in an amount effective to provide less than or equal to 2.0 weight % of the hydrogen peroxide.

### Claim 4 (depends on 1)

The mouthwash composition of claim 1, wherein the cyclic anhydride is at least one of maleic anhydride, succinic anhydride, naphthalenetetracarboxylic dianhydride, phthalic anhydride, chloromaleic anhydride, and dichloromaleic anhydride.

### Claim 5 (depends on 1)

The mouthwash composition of claim 1, wherein the cyclic anhydride is maleic anhydride.

### Claim 6 (depends on 1)

The mouthwash composition of claim 1, wherein the peracid is maleic peracid.

### Claim 7 (depends on 1)

The mouthwash composition of claim 1, wherein the cyclic anhydride is succinic anhydride.

### Claim 8 (depends on 7)

The mouthwash composition of claim 7, wherein the peracid is succinic peracid.

### Claim 9 (depends on 1)

The mouthwash composition of claim 1, wherein the molar ratio of the cyclic anhydride to the hydrogen peroxide provided by the source of hydrogen peroxide is about 1:1.

### Claim 10 (depends on 1)

The mouthwash composition of claim 1, wherein the peracid is generated in less than or equal to three minutes after contacting the hydrogen peroxide and the cyclic anhydride with one another.

### Claim 11 (depends on 1)

The mouthwash composition of claim 1, further comprising a fluoride ion source.

### Claim 12 (depends on 1)

The mouthwash composition of claim 1, further comprising a surfactant.

### Claim 13 (depends on 1)

A method for whitening teeth of a subject, comprising contacting the mouthwash composition of claim 1 with surfaces of the teeth of the subject in need thereof.

### Claim 14

A method for generating a whitening agent in a mouthwash composition, comprising contacting a cyclic anhydride and hydrogen peroxide with one another in the presence of sodium carbonate, wherein the whitening agent is a peracid; and
wherein the cyclic anhydride is not a polymer-based cyclic anhydride.