# US 11,110,044 B2 · Skincare treatment > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,110,044 B2 - Document ID: US11110044B2 - Status: Granted - Kind: B2 - Application number: 15/590,618 - Filed: 2017-05-09 - Published: 2017-08-31 - Granted: 2021-09-07 - Earliest claimed: 2008-01-04 - Assignees: Reckitt & Colman (Overseas) Health Limited - Applicants: Reckitt & Colman (Overseas) Limited - Inventors: Rebecca Horne; Diane Kelly; Laurent Kirchhoffer; Richard Koontz; James Young - Web page: https://patentgrep.com/patent/US11110044B2 ## CPC - A61K 8/36: Carboxylic acids; Salts or anhydrides thereof - A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings - A61K 31/60: Salicylic acid; Derivatives thereof - A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay} - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 17/10: Anti-acne agents - A61Q 19/00: Preparations for care of the skin - A61K 2800/242: Exothermic; Self-heating; Heating sensation - A61K 2800/31: Anhydrous - A61K 2800/88: Two- or multipart kits - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The invention relates to a method of treating acne by the topical administration of an acne active ingredient in the presence of a) an anhydrous composition comprising a component that in the presence of water generates heat, and b) water. The invention also relates to an acne treatment kit comprising a first composition which is anhydrous and comprises a component that in the presence of water generates heat on the skin to which it is applied and a second composition which comprises an aqueous carrier, at least one of said compositions comprising an acne active ingredient, said compositions being stored in isolation from each other and being capable of generating heat when they are combined. ## Claims ### Claim 1 A method of treating acne comprising: topically administering an acne treating composition to an area of skin exhibiting symptoms of acne, the acne treating composition comprising an acne active ingredient in the presence of an anhydrous composition, wherein the acne active ingredient is selected from the group comprising tretinoin, adapalene, tazarotene, clindamycin, erythromycin, azelaic acid, benzoyl peroxide, hydrogen peroxide and salicylic acid; and topically administering an aqueous composition to the area of skin, wherein the anhydrous composition further comprises a component that generates heat on the area of skin in the presence of water, said component is selected from the group consisting of magnesium chloride, iron chloride, zinc chloride, magnesium oxide, calcium oxide, magnesium sulphate and calcium chloride. ### Claim 2 (depends on 1) The method according to claim 1, wherein the administration of the anhydrous composition and the aqueous composition is substantially simultaneous. ### Claim 3 (depends on 1) The method according to claim 1, wherein the acne active ingredient is present in the anhydrous composition. ### Claim 4 (depends on 1) The method according to claim 1, wherein the acne active ingredient is present in the aqueous composition. ### Claim 5 (depends on 1) The method according to claim 1, wherein the acne active ingredient is present in an amount of from 0.1% to 10% by weight of the combined anhydrous and aqueous compositions. ### Claim 6 (depends on 1) The method according to claim 1, wherein the acne active ingredient is present in an amount of 0.1% to 5% by weight of the anhydrous composition. ### Claim 7 (depends on 1) The method according to claim 1, wherein the acne active ingredient is present in an amount of 0.1% to 5% by weight of the aqueous composition. ### Claim 8 (depends on 1) The method according to claim 1, wherein the component activatable by water to generate heat on the skin is magnesium chloride. ### Claim 9 (depends on 1) The method according to claim 1, wherein said anhydrous composition comprises from 5% to 60% by weight of said component that generates heat in the presence of water. ### Claim 10 (depends on 1) The method according to claim 1, wherein the anhydrous composition comprises an anhydrous carrier. ### Claim 11 (depends on 10) The method according to claim 10, wherein the anhydrous carrier comprises a hydrocarbon material. ### Claim 12 (depends on 11) The method according to claim 11, wherein the anhydrous carrier comprises mineral oil. ### Claim 13 (depends on 1) The method according to claim 1, wherein the anhydrous composition comprises a surfactant. ### Claim 14 (depends on 13) The method according to claim 13, wherein the surfactant is selected from the group consisting of alkyl sulphates, alkyl ether sulphates, alpha-olefin sulphates, alkylsarcosinates and aryl-sulphonated derivatives thereof. ### Claim 15 (depends on 14) The method according to claim 14, wherein the surfactant is selected from the group consisting of sodium lauryl sulphate and sodium dodecyl sulphate. ### Claim 16 (depends on 13) The method according to claim 13, wherein the anhydrous composition comprises from 1% to 10% by weight surfactant. ### Claim 17 (depends on 1) The method according to claim 1, wherein the aqueous composition is a cleansing composition comprising a surfactant. ### Claim 18 (depends on 1) The method according to claim 1, wherein the aqueous composition is water.