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US 11,109,975 B2Granted
Articular cartilage repair
AssigneeCytex Therapeutics, Inc.
InventorsBradley T. Estes, Franklin Thomas Moutos, Farshid Guilak
Life of this patent
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Abstract
A scaffold is provided which facilitates integration of both bone and cartilage at an osteochondral lesion, thereby acting as a tissue engineered interface or tissue engineered junction between the two different tissues. The method and systems for engineering this interface may be acellular or may be loaded with cells prior to use.
Claims18
An osteochondral interface repair implant for implantation within an osteochondral lesion, comprising:
- a moldable biocompatible three-dimensional woven fiber scaffold constructed of a plurality of layers of woven fibers adapted to allow integration of tissue from the cartilage surface and bone surface upon implantation, the plurality of layers of woven fibers including:
- at least one first layer made of fibers oriented in an x-direction;
- at least one second layer made of fibers oriented in a y-direction, the y-direction orthogonal to the x-direction;
- and
- at least one fiber oriented in a z-direction, the z-direction orthogonal to both the x-direction and the y-direction,
- wherein the at least one first layer and the at least one second layer are connected to one another by the at least one fiber oriented in the z-direction,
- wherein at least a portion of the fibers are coated with an inorganic matrix from the group consisting of hydroxyapatite, calcium phosphate, calcium carbonate, alumina, zirconia, yttria-stabilized zirconia, silicon nitride-based materials, bioactive glass, and/or glass ceramics,
- wherein each of the fibers comprises a plurality of yarns, and the yarns of all of the fibers of the three-dimensional fiber scaffold are configured to be locked into a physical conformation with respect to one another after being molded such that the scaffold is structurally stable, and
- wherein the plurality of layers includes an upper cartilage layer including a first plurality of said plurality of layers defining a first pore size and a lower osteogenic layer including a second plurality of said plurality of layers defining a second pore size that is greater than said first pore size.
6 more elements
An osteochondral interface implant for implantation within an osteochondral lesion, comprising:
- a moldable biocompatible three-dimensional woven fiber scaffold constructed of a plurality of layers of woven fibers adapted to allow integration of tissue from the cartilage surface and bone surface upon implantation, the plurality of layers of woven fibers including:
- at least one first layer made of fibers oriented in an x-direction;
- at least one second layer made of fibers oriented in a y-direction, the y-direction orthogonal to the x-direction;
- and
- at least one fiber oriented in a z-direction, the z-direction orthogonal to both the x-direction and the y-direction, wherein:
- the at least one first layer and the at least one second layer are connected to one another by the at least one fiber oriented in the z-direction,
- each of the fibers comprises a plurality of yarns, and the yarns of all of the woven fibers of the three-dimensional fiber scaffold are configured to be locked into a physical conformation with respect to one another after the scaffold is molded such that the scaffold is structurally stable,
- wherein the plurality of layers includes an upper cartilage layer including a first plurality of said plurality of layers defining a first pore size and a lower osteogenic layer including a second plurality of said plurality of layers defining a second pore size that is greater than said first pore size.
5 more elements
Dependencies are inferred from the claim text.