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US 11,109,784 B2Granted
Metal-enzyme sandwich layers
AssigneeCalifornia Institute of Technology
InventorsDvin Adalian, Samson Chen, Muhammad M. Jilani, Axel Scherer, Xiomara Linnette Madero, Richard Smith
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Abstract
Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
Claims26
A sensing device comprising:
- a working electrode on a substrate;
- wherein:
- the working electrode comprises:
- a metallic layer contacting the substrate;
- an enzyme layer on the metallic layer;
- and
- a metallic porous layer on the enzyme layer,
- the metallic layer, the enzyme layer, and the metallic porous layer are configured to detect a target analyte through an electrochemical reaction, and
- the metallic porous layer is electrically connected to the metallic layer.
6 more elements
Dependencies are inferred from the claim text.