# US 11,109,779 B2 · Chemical modification of analyte permeable membrane for enhanced oxidative stability > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,109,779 B2 - Document ID: US11109779B2 - Status: Granted - Kind: B2 - Application number: 16/009,963 - Filed: 2018-06-15 - Published: 2018-12-13 - Granted: 2021-09-07 - Earliest claimed: 2012-12-28 - Assignees: Senseonics, Incorporated - Applicants: Senseonics, Incorporated - Inventors: Jeremy Emken; Philip Huffstetler; Todd Whitehurst; Masika Hinds; Mark Mortellaro; Abhi Chavan; Bryan Hays - Web page: https://patentgrep.com/patent/US11109779B2 ## CPC - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 5/1459: invasive, e.g. introduced into the body by a catheter - A61B 5/0031: {Implanted circuitry} - A61B 5/1451: {for interstitial fluid} - A61B 5/746: {Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms} - A61B 2560/0219: of externally powered implanted units - A61B 2562/162: Capsule shaped sensor housings, e.g. for swallowing or implantation - A61B 2562/18: Shielding or protection of sensors from environmental influences, e.g. protection from mechanical damage - A61B 2562/185: Optical shielding, e.g. baffles - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The sensor may include one or more of a first coating on an inner surface of the membrane, a second coating on an outer surface of the membrane, and a layer on the outside of the indicator element. One or more of the first coating, second coating, and layer may reduce deterioration of the indicator element by catalyzing degradation of reactive oxygen species (ROS). The one or more coatings on the membrane may increase the light blocking capability of the membrane, which may improve the accuracy of the sensor. ## Claims ### Claim 1 A sensor comprising: a sensor housing; an indicator element embedded within and/or covering at least a portion of the sensor housing; a membrane over at least a portion of the indicator element, wherein the membrane comprises an inner surface and an outer surface; a coating on one of the inner and outer surfaces of the membrane, wherein the coating reduces deterioration of the indicator element by catalyzing degradation of reactive oxygen species (ROS); and a layer on the outside of the indicator element, wherein the layer is between the indicator element and the membrane and reduces deterioration of the indicator element by catalyzing degradation of ROS. ### Claim 2 (depends on 1) The sensor of claim 1, wherein the coating is on the outer surface of the membrane. ### Claim 3 (depends on 1) The sensor of claim 1, wherein the coating is on the inner surface of the membrane, and the layer is between the indicator element and the coating on the inner surface of the membrane. ### Claim 4 (depends on 3) The sensor of claim 3, wherein the coating is a first coating, the sensor further comprises a second coating on the outer surface of the membrane, and the second coating reduces deterioration of the indicator element by catalyzing degradation of ROS. ### Claim 5 (depends on 4) The sensor of claim 4, wherein the first and second coatings are sputter coatings. ### Claim 6 (depends on 4) The sensor of claim 4, wherein the first and second coatings comprise platinum. ### Claim 7 (depends on 1) The sensor of claim 1, wherein the coating is a sputter coating. ### Claim 8 (depends on 1) The sensor of claim 1, wherein the coating comprises platinum. ### Claim 9 (depends on 1) The sensor of claim 1, wherein the layer comprises platinum. ### Claim 10 (depends on 1) The sensor of claim 1, wherein the layer is sputtered on the outside of the indicator element. ### Claim 11 (depends on 1) The sensor of claim 1, wherein the membrane with the coating on one of the inner and outer surfaces of the membrane is opaque. ### Claim 12 (depends on 1) The sensor of claim 1, wherein the membrane is attached to the sensor housing. ### Claim 13 (depends on 12) The sensor of claim 12, wherein the membrane is attached to the sensor housing by heat bonding or with a biocompatible adhesive. ### Claim 14 (depends on 12) The sensor of claim 12, wherein the membrane is attached to the sensor housing using laser bonding. ### Claim 15 (depends on 1) The sensor of claim 1, wherein the membrane is a mesh material. ### Claim 16 (depends on 1) The sensor of claim 1, wherein the membrane has pores configured to substantially prevent white blood cells from passing through the membrane but to permit the analyte to pass through the membrane. ### Claim 17 (depends on 16) The sensor of claim 16, wherein the analyte is glucose. ### Claim 18 (depends on 1) The sensor of claim 1, wherein the membrane is wrapped around the indicator element. ### Claim 19 (depends on 1) The sensor of claim 1, wherein the indicator element is a polymer graft including indicator molecules. ### Claim 20 (depends on 1) The sensor of claim 1, wherein one or more of the membrane and the coating are configured to block (i) external light from reaching the indicator element and (ii) light from the sensor housing that has passed through the indicator element from reaching the bodily tissue of the living animal.