# US 11,109,768 B2 · Tonometry based blood pressure measurements using a two-dimensional force sensor array > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,109,768 B2 - Document ID: US11109768B2 - Status: Granted - Kind: B2 - Application number: 15/627,911 - Filed: 2017-06-20 - Published: 2017-12-28 - Granted: 2021-09-07 - Earliest claimed: 2016-06-27 - Assignees: Northwestern University - Applicants: Northwestern University - Inventors: Sanjay Mehrotra; Ilya Mikhelson; Alan V. Sahakian - Web page: https://patentgrep.com/patent/US11109768B2 ## CPC - A61B 5/021: Measuring pressure in heart or blood vessels - A61B 5/02108: {from analysis of pulse wave characteristics} - A61B 5/6824: {Arm or wrist} - A61B 5/7214: {using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths} - A61B 5/02: Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow - A61B 2562/0247: Pressure sensors - A61B 2562/046: in a matrix array - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Representative methods, apparatus and systems are disclosed for blood pressure and other vital sign monitoring using arterial applanation tonometry, including ambulatory blood pressure and other vital sign monitoring. A representative system comprises a wearable apparatus. The various embodiments measure blood pressure and other vital sign monitoring using a plurality of pressure sensors of a pressure sensor array, with one or more of the pressure sensors 140 applanating an artery, such as a radial artery. In a first embodiment, a pressure sensor signal is utilized which has the highest cross-coherence with the signals of its nearest pressure sensor neighbors of the pressure sensor array. In a second embodiment, Kalman filtering is utilized for the pressure sensor signals from the pressure sensor array. ## Claims ### Claim 1 An apparatus for determining a blood pressure of a subject human being for ambulatory monitoring, the apparatus comprising: a pressure sensor array having a plurality of pressure sensors spaced-apart in at least two dimensions; and a processor coupled to the pressure sensor array, the processor adapted to: receive a plurality of pressure sensor signals, one or more of the pressure sensor signals having data representing amplitudes of one or more arterial pressure waves; determine a frequency content of each of the one or more of the pressure sensor signals having data; select one or more pressure sensor signals to form a first plurality of selected pressure sensor signals; select one or more pressure sensor signals within a predetermined deviation of a mean of the first plurality of selected pressure sensor signals to form a second plurality of selected pressure sensor signals; determine, for each pressure sensor signal in the second plurality of selected pressure sensor signals, a cross-coherence with each nearest neighbor pressure sensor signal; identify a pressure sensor signal having a highest mean cross-coherence; and determine, based on the pressure sensor signal having the highest mean cross-coherence, a systolic blood pressure value and a diastolic blood pressure value. ### Claim 2 (depends on 1) The apparatus of claim 1, further comprising: a housing coupled to the pressure sensor array and to the processor; and a wearable attachment coupled to the housing. ### Claim 3 (depends on 1) The apparatus of claim 1, wherein the processor is further adapted to determine the systolic blood pressure value as a maximum of the pressure sensor signal having the highest mean cross-coherence; and determine the diastolic blood pressure value as a minimum of the pressure sensor signal having the highest mean cross-coherence. ### Claim 4 (depends on 1) The apparatus of claim 1, wherein the processor is further adapted to perform a first filtering of the plurality of pressure sensor signals to eliminate one or more pressure sensor signals below a predetermined threshold. ### Claim 5 (depends on 1) The apparatus of claim 1, wherein the processor is further adapted, using one or more pressure sensor signals from the second plurality of selected pressure sensor signals, to determine a heart rate. ### Claim 6 (depends on 1) The apparatus of claim 1, wherein the processor is further adapted to perform a Kalman filtering of the second plurality of selected pressure sensor signals; determine the systolic blood pressure value as a maximum of the Kalman filter data; and determine the diastolic blood pressure value as a minimum of the Kalman filter data. ### Claim 7 (depends on 1) The apparatus of claim 1, further comprising: a display for displaying the determined blood pressure value and other vital sign information to the user. ### Claim 8 (depends on 1) The apparatus of claim 1, further comprising: a wireless transmitter to transmit the determined blood pressure value and other vital sign information to a central location. ### Claim 9 (depends on 1) The apparatus of claim 1, further comprising: a network interface circuit to transmit the determined blood pressure value and other vital sign information to a central location. ### Claim 10 (depends on 1) The apparatus of claim 1, further comprising: a memory circuit storing the determined blood pressure value and other vital sign information. ### Claim 11 A system for determining a blood pressure of a subject human being for ambulatory monitoring, the system comprising: a wearable apparatus comprising: a pressure sensor array having a plurality of pressure sensors spaced-apart in at least two dimensions, the pressure sensor array generating a plurality of pressure sensor signals, one or more of the pressure sensor signals having data representing amplitudes of one or more arterial pressure waves; and a wireless transmitter coupled to the pressure sensor array to transmit the plurality of pressure sensor signals; a central monitor, comprising: a memory circuit; a wireless transceiver to receive the transmitted plurality of pressure sensor signals; and a processor coupled to the wireless transceiver and to the memory circuit, the processor adapted to: determine a frequency content of each of the one or more of the pressure sensor signals having data; select one or more pressure sensor signals to form a first plurality of selected pressure sensor signals; select one or more pressure sensor signals within a selected deviation of a mean of the first plurality of selected pressure sensor signals to form a second plurality of selected pressure sensor signals; determine, for each pressure sensor signal in the second plurality of selected pressure sensor signals, a cross-coherence with each nearest neighbor pressure sensor signal; identify a pressure sensor signal having a highest mean cross-coherence; and determine, based on the pressure sensor signal having the highest mean cross-coherence, a systolic blood pressure value and a diastolic blood pressure value. ### Claim 12 (depends on 11) The system of claim 11, wherein the wearable apparatus further comprises: a housing coupled to the pressure sensor array; and a wearable attachment coupled to the housing. ### Claim 13 (depends on 11) The system of claim 11, wherein the processor is further adapted to perform a first filtering of the plurality of pressure sensor signals to eliminate one or more pressure sensor signals below a predetermined threshold; to determine the systolic blood pressure value as a maximum of the pressure sensor signal having the highest mean cross-coherence; and determine the diastolic blood pressure value as a minimum of the pressure sensor signal having the highest mean cross-coherence.