Method for tuning patient-specific cardiovascular simulations

A computer-implemented method for determining cardiovascular information from patient-specific image data to predict a hemodynamic result of a medical intervention for a patient using at least one computer system, the method comprising:

• receiving, at the at least one computer system, patient-specific image data regarding a geometry of an anatomical structure of the patient;
• creating, using the at least one computer system and based on the patient-specific image data, a three-dimensional model representing at least a portion of the anatomical structure of the patient, the three-dimensional model including portions representing at least one inlet and at least one outlet for blood flow;
• determining one or more boundary condition parameters for the at least one of the at least one inlet or the at least one outlet of the three-dimensional model;
• executing, using the at least one computer system, a three-dimensional simulation on the three-dimensional model, based on the determined one or more boundary condition parameters, to determine a blood flow characteristic within the anatomical structure of the patient;
• creating, based on the executed three-dimensional simulation, a reduced-order model that is computationally faster than the three-dimensional model and that represents at least part of the portion of the anatomical structure of the patient represented by the three-dimensional model;
• determining a medical intervention to be simulated using the reduced-order model;
• and
• predicting a hemodynamic result of the medical intervention for the patient by solving the reduced-order model to determine an update to the blood flow characteristic.

A non-transitory computer readable medium for use on at least one computer system containing computer-executable programming instructions for performing a method for determining patient-specific cardiovascular information from received patient-specific image data to predict a hemodynamic result of a medical intervention for a patient, the method comprising:

• receiving patient-specific image data regarding a geometry of an anatomical structure of the patient;
• creating, based on the patient-specific image data, a three-dimensional model representing at least a portion of the anatomical structure of the patient, the three-dimensional model including portions representing at least one inlet and at least one outlet for blood flow;
• determining one or more boundary condition parameters for the three-dimensional model for the at least one inlet or at least one outlet of the three-dimensional model;
• executing, using the at least one computer system, a three-dimensional simulation on the three-dimensional model, based on the determined one or more boundary condition parameters, to determine a blood flow characteristic within the anatomical structure of the patient;
• creating, based on the executed three-dimensional simulation, a reduced-order model that is computationally faster than the three-dimensional model and that represents at least part of the portion of the anatomical structure of the patient represented by the three-dimensional model;
• determining a medical intervention to be simulated using the reduced-order model;
• and
• predicting a hemodynamic result of the medical intervention for the patient by solving the reduced-order model to determine an update to the blood flow characteristic.