In vivo detection of EGFR mutation in glioblastoma via MRI signature consistent with deep peritumoral infiltration

A method for targeted treatment of a patient having a neoplasm associated with an epidermal growth factor receptor (EGFR) mutation, the method comprising:

• (a) detecting an epidermal growth factor receptor variant (EGFR) mutation status within peritumoral edematous tissue of a patient using a computer-implemented method for in vivo detection of an epidermal growth factor receptor (EGFR) mutation status within peritumoral edematous tissue, comprising executing on a processor the steps of:
• performing quantitative pattern analysis of magnetic resonance imaging (MRI) data corresponding to MRI of in vivo peritumoral edematous tissue to determine a level of spatial heterogeneity or similarity within the in vivo peritumoral edematous tissue;
• assigning EGFR mutation status as one of negative or positive based on the level of spatial heterogeneity or similarity determined during said performing step;
• and
• (b) treating a patient with a EGFR-targeting therapy.