Vaccinia virus vectors related to MVA with extensive genomic symmetries

A Modified Vaccinia Ankara (MVA) related virus comprising one or more of the following features:

• (i) a nucleic acid sequence corresponding to a region that includes the right Inverted Terminal Repeat (ITR) and extends to but excludes deletion site III instead of a nucleic acid sequence that includes the left Inverted Terminal Repeat (ITR) and extends to but excludes deletion site V, wherein the region that includes the right ITR and extends to but excludes deletion site III has a nucleic acid sequence according to SEQ ID NO:
• 37 or Genbank Accession number KY633487 or is a variant thereof which is at least 95% identical to said nucleic acid sequence, and/or wherein the region that includes the left ITR and extends to but excludes deletion site V has a nucleic acid sequence according to SEQ ID NO:
• 37 or Genbank Accession number KY633487 or is a variant thereof which is at least 95% identical to said nucleic acid sequence,
• and
• (ii) two copies of a nucleic acid sequence comprising deletion site IV and the right ITR, wherein the nucleic acid sequence comprising deletion site IV and the right ITR has a nucleic acid sequence according to SEQ ID NO:
• 37 or Genbank Accession number KY633487 or is a variant thereof which is at least 95% identical to said nucleic acid sequence.