Antibodies to quetiapine and use thereof
AssigneeJanssen Pharmaceutica NV
InventorsEric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Bart M. Remmerie, Rhys Salter, Matthew G. Donahue, Yong Gong
Life of this patent
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Abstract
Disclosed is an antibody or a binding fragment thereof which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody or the fragment thereof can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.
Claims21
An isolated antibody or a binding fragment thereof, which specifically binds to quetiapine, the isolated antibody or the binding fragment thereof comprising:
- (a) a light chain complementarity determining region (CDR) 1 sequence comprising amino acid residues 43 to 58 of SEQ ID NO:3, a light chain CDR2 sequence comprising amino acid residues 74 to 80 of SEQ ID NO:3, a light chain CDR3 sequence comprising amino acid residues 113 to 121 of SEQ ID NO:3, a heavy chain CDR1 sequence comprising amino acid residues 50 to 54 of SEQ ID NO:4, a heavy chain CDR2 sequence comprising amino acid residues 69 to 84 of SEQ ID NO:4, and a heavy chain CDR3 sequence comprising amino acid residues 117 to 126 of SEQ ID NO:4;
- (b) a light chain CDR1 sequence comprising amino acid residues 43 to 58 of SEQ ID NO:8, a light chain CDR2 sequence comprising amino acid residues 74 to 80 of SEQ ID NO:8, a light chain CDR3 sequence comprising amino acid residues 113 to 121 of SEQ ID NO:8, a heavy chain CDR1 sequence comprising amino acid residues 45 to 54 of SEQ ID NO:10, a heavy chain CDR2 sequence comprising amino acid residues 69 to 84 of SEQ ID NO:10, and a heavy chain CDR3 sequence comprising amino acid residues 117 to 119 of SEQ ID NO:10;
- (c) a light chain CDR1 sequence comprising amino acid residues 46 to 56 of SEQ ID NO:9, a light chain CDR2 sequence comprising amino acid residues 72 to 78 of SEQ ID NO:9, a light chain CDR3 sequence comprising amino acid residues 111 to 119 of SEQ ID NO:9, a heavy chain CDR1 sequence comprising amino acid residues 49 to 54 of SEQ ID NO:10, a heavy chain CDR2 sequence comprising amino acid residues 69 to 84 of SEQ ID NO:10, and a heavy chain CDR3 sequence comprising amino acid residues 117 to 119 of SEQ ID NO:10;
- or
- (d) a light chain CDR1 sequence comprising amino acid residues 46 to 55 of SEQ ID NO:17, a light chain CDR2 sequence comprising amino acid residues 71 to 77 of SEQ ID NO:17, a light chain CDR3 sequence comprising amino acid residues 110 to 118 of SEQ ID NO:17, a heavy chain CDR1 sequence comprising amino acid residues 50 to 54 of SEQ ID NO:18, a heavy chain CDR2 sequence comprising amino acid residues 69 to 85 of SEQ ID NO:18, and a heavy chain CDR3 sequence comprising amino acid residues 118 to 128 of SEQ ID NO:18.
Dependencies are inferred from the claim text.