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US 11,104,709 B2Granted
Mutant pore
AssigneeOxford Nanopore Technologies PLC
InventorsLakmal Jayasinghe, Mark John Bruce, Luke McNeill, Ramiz Iqbal Nathani, Pratik Raj Singh, Neil Roger Wood, Stephen Robert Young
Life of this patent
Estimating the term…
Abstract
The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.
Claims1
A mutant lysenin monomer comprising a variant of the amino acid sequence set forth in SEQ ID NO:
- 2, wherein the variant comprises one of the following combinations of amino acid substitutions:
- E94D/K99Q/T106K;
- E94D/T93K/T106K;
- E94D/T91K/T106K;
- H83K/E94D/T106K;
- E94Q/Y96D/T106K;
- K45D/E94K/T106K;
- K45R/E94D/T106K;
- E94D/S98K/K99L/T106K;
- K37N/E94D/T106K;
- K37W/E94D/T106K;
- K37S/E94D/T106K;
- K45N/E94N/T106K;
- K37Q/E94D/E102N/T106K;
- K37S/E94D/E102S/T106K;
- K37S/E94D/T104K/T106K;
- K45Q/E94Q/T106K;
- K45T/V47K/E94D/T106K;
- V47S/E94D/T106K;
- T51K/E94D/T106K;
- K45Y/S49K/E94D/T106K;
- S49L/E94D/T106K;
- K45R/T106K;
- V47K/E94D/T106K;
- G43K/E94D/T106K;
- V88I/M90A/E94D/T106K;
- V47N/V88T/E94D/T106K;
- K45N/S49K/E94N/E92D/T106K;
- K45N/V47K/E92D/E94N/T106K;
- or
- E94D/K99Q/T106K.
28 more elements
Dependencies are inferred from the claim text.