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US 11,104,687 B2Granted
Solid forms for a thienopyrimidinedione ACC inhibitor and methods for production thereof
AssigneeGilead Apollo, LLC
InventorsGeraldine C. Harriman, Jon P. Lawson, Xiaowei Yang
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Abstract
The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.
Claims5
A process for preparing an enantiomerically enriched compound of formula (R)-G-5:
- wherein Ra is an optionally substituted group selected from a 3-7 membered ring having 0-2 heteroatoms selected from nitrogen, oxygen, and sulfur, and C1-6 aliphatic;
- R2 is hydrogen or optionally substituted C1-6 aliphatic;
- and
- R5 is hydrogen or halogen;
- comprising the steps of:
- a) contacting a racemic compound of formula rac-G-5
- with a lipase enzyme and a [acyl] donor, thereby forming a compound of formula (R)-G-8:
- wherein [acyl] is a C1-C7 acyl group;
- and
- b) removing the [acyl];
- thereby preparing the enantiomerically enriched compound of formula (R)-G-5.
8 more elements
Dependencies are inferred from the claim text.