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US 11,103,578 B2Granted
Respiratory virus nucleic acid vaccines
AssigneeModernaTX, Inc.
InventorsGiuseppe Ciaramella, Sunny Himansu
Life of this patent
Estimating the term…
Abstract
Provided herein, in some embodiments, are vaccines (and vaccination methods) that include a ribonucleic acid (RNA) polynucleotide encoding a human metapneumovirus (hMPV) F protein and a RNA polynucleotide encoding a human parainfluenza virus 3 (hPrV3) F protein.
Claims28
A composition comprising:
- a human metapneumovirus (hMPV) messenger ribonucleic acid (mRNA) comprising a 5′ UTR that comprises the sequence of SEQ ID NO:12, an open reading frame that comprises the sequence of SEQ ID NO:4, and a 3′ UTR that comprises the sequence of SEQ ID NO:13;
- and
- a human parainfluenza virus 3 (hPIV3) mRNA comprising a 5′ UTR that comprises the sequence of SEQ ID NO:12, an open reading frame that comprises the sequence of SEQ ID NO:5, and a 3′ UTR that comprises the sequence of SEQ ID NO:13.
A composition comprising:
- 25 μg-200 μg human metapneumovirus (hMPV) messenger ribonucleic acid (mRNA) comprising the sequence of SEQ ID NO:14;
- and
- 25 μg-200 μg a human parainfluenza virus 3 (hPIV3) mRNA comprising the sequence of SEQ ID NO:15.
Dependencies are inferred from the claim text.