Infectious disease vaccine using non-infectious paramyxovirus particle
AssigneesJapan AS Represented By the Director-General of National Institute of Infectious Disease, ID Pharma Co., Ltd.
InventorsTetsuro Matano, Makoto Inoue, Hiroto Hara, Tsugumine Shu
Life of this patent
Estimating the term…
Abstract
In this invention, a non-infectious particle has been produced, comprising a pathogen antigen protein caused to be expressed on the surface of a virus particle having at least one species of paramyxovirus envelope protein missing from the particle. This particle has been found to hold within the particle a large amount of antigen protein compared to an infectious particle, and to be capable of eliciting a host immune response with extremely high efficiency. The non-infectious particle according to the present invention is useful as a vaccine against a pathogenic virus, or the like.
Claims13
A F gene-deleted Sendai virus non-infectious particle, which lacks F protein of the Sendai virus on the surface of the virus particle, and holds an antigen protein of a heterologous pathogen on the surface of the virus particle, wherein the antigen protein of the heterologous pathogen is a fusion protein containing an antigen fragment of the pathogen at the outer side of the virus particle and a cytoplasmic region fragment of the F protein at the inner side of the virus particle.
Dependencies are inferred from the claim text.