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OwnerOlivia Yee-Yee Lam, Dominic Man-Kit Lam +2inventors
InventorsOlivia Yee-Yee Lam, Dominic Man-Kit Lam, Han Lei, Fong Wilson Lam
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In the invention described here, the approach is to formulate an edible vaccine based on N-terminal yeast surface display expression systems including S. cerevisiae EBY100/pYD5-VP28, S. cerevisiae EBY100/pYD5-VP28-VP24 and S. cerevisiae EBY100/pYD5-VP24 for preventing shrimps such as L. vannamei, P. monodon and M. rosenbergii species from white spot syndrome virus (WSSV) infection, suggesting that yeast surface display expression system expressing WSSV antigen has potential as a prophylactic treatment for WSSV in shrimps via oral vaccination. The technology developed in this patent application can also be used to produce edible (oral) vaccines for preventing and treating other infectious diseases in animals and human.
A method of immunizing shrimp against white spot syndrome virus (WSSV) comprising the step of administering to the shrimp a shrimp pellet feed coated with a recombinant yeast cell, wherein said recombinant yeast cell expresses, on its surface, a white spot syndrome virus (WSSV) antigen selected from the group consisting of VP24, VP28, and a combination of VP24 and VP28.
A method of making a vaccine against white spot syndrome virus (WSSV) comprising a step of:
Dependencies are inferred from the claim text.