Clotting composition
AssigneeQ-Sera Pty Ltd.
InventorsPaul Masci, Kong-Nan Zhao, Martin Lavin, John De Jersey, Goce Dimeski
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Abstract
The present invention relates to improved clotting compositions for producing high quality blood serum samples for analyte testing, such as for pathology testing and other biological assays. In particular, the present invention relates to the use of prothrombin activators in combination with stabilizing agents such as colloids for producing high quality blood serum samples. The present invention also relates to associated methods for preparing clotting compositions, tubes, kits and methods of diagnosis, prognosis and monitoring for responsiveness to therapy.
Claims3
A clotting composition for preparing a serum sample, wherein the clotting composition comprises a prothrombin activator and a colloid, wherein the prothrombin activator and the colloid are present in an amount that is sufficient to produce a serum sample when the clotting composition is added to a blood sample, wherein the prothrombin activator is a group A snake venom prothrombin activator or a group C snake venom prothrombin activator, and the colloid is a gelatin-based colloid, an albumin-based colloid or a dextran-based colloid.
A method for preparing a serum sample comprising contacting a blood sample with a clotting composition under conditions sufficient to cause clotting of the blood sample, thereby preparing a serum sample, wherein the clotting composition comprises a prothrombin activator and a colloid, wherein the prothrombin activator is a group A snake venom prothrombin activator or a group C snake venom prothrombin activator, and the colloid is a gelatin-based colloid, an albumin-based colloid or a dextran-based colloid.
Dependencies are inferred from the claim text.