Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use

A composition for administering ketone bodies to a subject, comprising:

• a non-racemic mixture of R-beta-hydroxybutyrate and S-beta-hydroxybutyrate containing more than 50% and less than 100% by enantiomeric equivalents of R-beta-hydroxybutyrate and less than 50% and more 0% by enantiomeric equivalents of S-beta-hydroxybutyrate, wherein the non-racemic mixture of R-beta-hydroxybutyrate and S-beta-hydroxybutyrate includes:
• at least one R-beta-hydroxybutyrate salt or ester;
• at least one S-beta-hydroxybutyrate salt or ester;
• and
• at least one of R- or S-beta-hydroxybutyric acid,
• wherein the non-racemic mixture comprises at least 99.6% and less than 100% by molar equivalents of combined R-beta-hydroxybutyrate and S-beta-hydroxybutyrate salts,
• wherein the non-racemic mixture comprises greater than 0% and up to 0.4% by molar equivalents of the at least one of R- or S-beta-hydroxybutyric acid, and
• wherein the composition is provided as or in a tablet, capsule, powder, food product, food additive, flavored beverage, vitamin fortified beverage, non-alcoholic beverage, flavored beverage additive, vitamin fortified beverage additive, non-alcoholic beverage additive, candy, sucker, pastille, food supplement, flavored mouth spray, or suppository.

A composition for administering ketone bodies to a subject, comprising:

• a dietetically or pharmaceutically acceptable carrier selected from the group consisting of tablet, capsule, powder, food product, food additive, flavored beverage, vitamin fortified beverage, non-alcoholic beverage, flavored beverage additive, vitamin fortified beverage additive, non-alcoholic beverage additive, candy, sucker, pastille, food supplement, flavored mouth spray, and suppository;
• and
• a non-racemic mixture of R-beta-hydroxybutyrate and S-beta-hydroxybutyrate containing more than 50% and less than 100% by enantiomeric equivalents of R-beta-hydroxybutyrate and less than 50% and more 0% by enantiomeric equivalents of S-beta-hydroxybutyrate, wherein the non-racemic mixture of R-beta-hydroxybutyrate and S-beta-hydroxybutyrate includes:
• at least one R-beta-hydroxybutyrate salt or R-beta-hydroxybutyrate ester;
• at least one S-beta-hydroxybutyrate salt or S-beta-hydroxybutyrate ester;
• and
• at least one of R- or S-beta-hydroxybutyric acid,
• wherein the non-racemic mixture comprises at least 99.6% and less than 100% by molar equivalents of combined R-beta-hydroxybutyrate and S-beta-hydroxybutyrate salts, and
• wherein the non-racemic mixture comprises greater than 0% and up to 0.4% by molar equivalents of the at least one of R- or S-beta-hydroxybutyric acid.