Back to results
US 11,098,014 B2Granted
Aryl isonitriles as a new class of antimicrobial compounds
AssigneePurdue Research Foundation
InventorsMohamed Seleem, Mingji Dai, Dexter Cameron Davis, Haroon Taj Mohammad
Life of this patent
Estimating the term…
Abstract
The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.
Claims8
A method for inhibiting MRSA comprising contacting MRSA with an isonitrile compound having the structure:
- wherein R is a hydrogen, an alkyl, a cycloalkyl, a heteroalkyl, or an aryl group;
- n is an integer from 0 to 4;
- X is hydrogen, a C1 to C3 alkyl group, a halogen, alkyloxy, trihalomethyl, or a nitro group;
- W, Y, and Z are each independently —CH— or N with one and only one of W, Y, or Z is N;
- and
- pharmaceutically acceptable salts thereof.
3 more elements
A method for treating a patient having a MRSA infection comprising administering to the patient a therapeutically effective amount of an isonitrile compound having the structure:
- wherein R is a hydrogen, an alkyl, a cycloalkyl, a heteroalkyl, or an aryl group;
- n is an integer from 0 to 4;
- X is hydrogen, a C1 to C3 alkyl group, a halogen, alkyloxy, trihalomethyl, or a nitro group;
- W, Y, and Z are each independently —CH— or N with one and only one of W, Y, or Z is N;
- and
- pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.