Crystal of amino acid salt of 3-hydroxyisovaleric acid and production method thereof
AssigneesKyowa Hakko Bio Co., Ltd., Otsuka Pharmaceutical Factory, Inc.
InventorsTomoya Yokoi, Hiroshi Nagano, Takayuki Shimizu
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Abstract
An object of the present invention is to provide a crystal of an amino acid salt of HMB which is easy to handle and has high solubility, and to provide a method for producing the same. According to the present invention, the crystal of an amino acid salt of HMB can be precipitated by dissolving an amorphous amino acid salt of HMB in a solvent containing alcohol and stirring or allowing the solvent to left stand. In addition, the crystal of an amino acid salt of HMB can be precipitated by concentrating an aqueous HMB solution of an amino acid salt which has a pH of 2.5 to 11.0.
Claims20
A crystal of an amino acid salt of a 3-hydroxyisovaleric acid (HMB) wherein
- (i) the amino acid salt of HMB is an arginine salt of HMB, and in powder X-ray diffraction, the crystal has peaks at diffraction angles (2θ) of 7.5±0.2°, 14.5±0.2°, 15.1±0.2°, 19.2±0.2°, and 20.2±0.2°,
- (ii) the amino acid salt of HMB is a lysine salt of HMB, and in powder X-ray diffraction, the crystal has peaks at diffraction angles (2θ) of 8.5±0.2°, 17.0±0.2°, 18.1±0.2°, 18.5±0.2°, and 19.5±0.2°,
- (iii) the amino acid salt of HMB is an ornithine salt of HMB, and in powder X-ray diffraction, the crystal has peaks at diffraction angles (2θ) of 5.1±0.2°, 14.0±0.2°, 15.3±0.2°, 20.4±0.2°, and 21.9±0.2°, or
- (iv) the amino acid salt of HMB is an ornithine salt of HMB, and in powder X-ray diffraction, the crystal has peaks at diffraction angles (2θ) of 4.9±0.2°, 5.2±0.2°, 5.5±0.2°, 10.9±0.2° and 15.5±0.2°.
Dependencies are inferred from the claim text.